Self-assessed parental depressive problems are associated with blunted cortisol responses to a social stress test in daughters. The TRAILS Study
Self-assessed parental depressive problems are associated with blunted cortisol responses to a social stress test in daughters. The TRAILS Study
复制标题
DOI：
10.1016/j.psyneuen.2010.11.008
复制
发表时间：
2011-07-01
影响因子：
3.7
通讯作者：
Oldehinkel, Albertine J.
中科院分区：
文献类型：
--
作者：
Bouma, Esther M. C.;Riese, Harriette;Oldehinkel, Albertine J.
抑郁症有家族遗传性，被认为是一种与压力有关的疾病。家族性抑郁症风险可能通过父母对心理生理应激反应的失调而传播给孩子。在这项研究中，我们研究了自我评估的终生父母抑郁问题（PDP）与青少年后代皮质醇对社会压力测试的反应之间的关联。数据收集是 TRAILS（跟踪青少年个人生活调查）第三次评估的一部分，这是一项针对荷兰青少年的大型前瞻性人口研究。研究人员对参加实验室课程的 330 名青少年（平均年龄 16.04 岁；40.9% 是女孩）的数据进行了检查，其中包括标准化的与表现相关的社会压力任务（公开演讲和心算）。在社会压力任务之前、期间和之后收集了四个唾液皮质醇样本，并通过重复测量方差分析进行分析。通过亲生父母的自我报告来评估父母一生的抑郁问题。 PDP 与女儿的皮质醇反应相关（F(3,133) = 3.90，p = .02），但在儿子中未发现关联（F(3,193) = 0.27，p = .78）。父母曾经经历过抑郁症状的女孩对标准化社会压力测试表现出迟钝的皮质醇反应，而父母从未出现过此类问题的女孩则表现出特征性的曲线反应模式。这种效应不是由后代应激史（0-16 岁）介导的。对吸烟行为和青少年抑郁情绪的分析进行了校正。事实上，PDP 是通过自我报告问卷测量的，不能反映临床 DSM-IV 诊断，这一事实可以被认为是该研究的局限性。 (C) 2010 Elsevier Ltd. 保留所有权利。
Depression runs in families and is considered a stress-related disorder. Familial risk for depression may be transmitted via deregulated psychophysiological stress responses from parent to child. In this study, we examined the association between self-assessed lifetime parental depressive problems (PDP) and adolescent offspring' cortisol responses to a social stress test. Data were collected as part of the third assessment wave of TRAILS (TRacking Adolescents' Individual Lives Survey), a large prospective population study of Dutch adolescents. Data of 330 adolescents (mean age 16.04; 40.9% girls) who participated in a laboratory session, including a standardized performance-related social stress task (public speaking and mental arithmetic) were examined. Four saliva cortisol samples were collected before, during and after the social stress task which were analyzed with repeated measures Analysis of Variance. Lifetime parental depressive problems were assessed by self-reports from both biological parents. PDP was associated with daughter' cortisol responses (F(3,133) = 3.90, p = .02), but no association was found in sons (F(3,193) = 0.27, p = .78). Girls whose parents ever experienced depressive symptoms displayed a blunted cortisol response to the standardized social stress test, while girls whose parents never had such problems displayed the characteristic curvilinear response pattern. This effect was not mediated by offspring stress history (age 0-16). Analyses were corrected for smoking behaviour and adolescent depressed mood. The fact that PDP were measured by self-report questionnaires and did not reflect clinical DSM-IV diagnosis could be considered a limitation of the study. (C) 2010 Elsevier Ltd. All rights reserved.