LOCALIZATION OF PDGF-B PROTEIN IN MACROPHAGES IN ALL PHASES OF ATHEROGENESIS
LOCALIZATION OF PDGF-B PROTEIN IN MACROPHAGES IN ALL PHASES OF ATHEROGENESIS
复制标题
DOI：
10.1126/science.2343305
复制
发表时间：
1990-05-25
期刊：
影响因子：
56.9
通讯作者：
SATO, H
中科院分区：
文献类型：
--
作者：
ROSS, R;MASUDA, J;SATO, H
动脉粥样硬化病变发生在动脉壁的最内层，主要由增殖的平滑肌细胞组成，周围有大量的结缔组织、大量充满脂质的巨噬细胞和不同数量的淋巴细胞。生长调节分子可能参与了动脉粥样硬化闭塞性病变的内膜积聚和平滑肌细胞增殖。血小板源性生长因子（PDGF）B链蛋白在人类和非人类灵长类动物动脉粥样硬化病变发展的所有阶段的巨噬细胞内被发现。因此，巨噬细胞可能通过向内膜平滑肌细胞提供PDGF（一种有效的趋化性和生长刺激分子）而在疾病中发挥关键作用。
Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Plate-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.