Noisy signal amplification in ultrasensitive signal transduction
Noisy signal amplification in ultrasensitive signal transduction
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DOI：
10.1073/pnas.0403350102
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发表时间：
2005-01-11
影响因子：
11.1
通讯作者：
Fujimoto, K
中科院分区：
文献类型：
--
作者：
Shibata, T;Fujimoto, K
由于细胞内过程固有地是有噪声的，随机反应在细胞信号转导中处理噪声信号。生物信号转导系统的一个基本特征是放大输入信号中的微小变化。然而，输入信号中的小的随机变化也可能被放大，并且转导反应也可能产生噪声。在这里，我们从理论上表明如何突然响应的超灵敏的信号转导反应的结果在产生大的固有噪声和输入噪声的高放大。固有产生的噪声通过细胞内分子网络放大传播。我们将讨论如何通过实验证明这种传输噪声的贡献。我们的研究结果表明，开关样的信号转导行为可能会受到噪音的限制;然而，高放大反应可能有利于产生大的噪音，这将是必要的，以维持行为的可变性。
Because intracellular processes are inherently noisy, stochastic reactions process noisy signals in cellular signal transduction. One essential feature of biological signal transduction systems is the amplification of small changes in input signals. However, small random changes in the input signals could also be amplified, and the transduction reaction can also generate noise. Here, we show theoretically how the abrupt response of ultrasensitive signal-transduction reactions results in the generation of large inherent noise and the high amplification of input noise. The inherently generated noise propagates with amplification through intracellular molecular network. We discuss how the contribution of such transmitted noise can be shown experimentally. Our results imply that the switch-like behavior of signal transduction could be limited by noise; however, high amplification reaction could be advantageous to generate large noise, which would be essential to maintain behavioral variability.