Cancer Targeted Drug Delivery
Cancer Targeted Drug Delivery
复制标题
DOI：
10.1007/978-1-4614-7876-8
复制
发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Y. Bae;R. Mrsny;Kinam Park
中科院分区：
文献类型：
--
作者：
Y. Bae;R. Mrsny;Kinam Park
癌症是没人欢迎的东西。然而，它是随机造访我们的。一旦癌症出现在我们的家门口，它就不会消失。如果我们能弄清楚癌症为什么以及什么时候来拜访我们中的任何一个人，那就好了。多年来，癌症治疗已经变得更加有效，至少对一些癌症来说是这样，但总体上癌症很少被治愈。开发新的有效药物很重要，但大多数药物都有副作用。只要益处大于副作用，药物就是有用的，但最终目标是让药物没有副作用。药物递送系统的功能之一是在最大化药理效果的同时最小化副作用。尽管目前的药物递送系统在提高效益/风险比方面取得了良好的效果，但技术仍需大幅改进。因此，我们问了一个简单而又根本性的问题：为什么治愈癌症如此困难？癌症不是一种单一的疾病，可以通过一种药物根除。癌症的发生原因多种多样，没有两种癌症是完全相同的。为了提高我们成功治疗癌症的机会，取决于我们如何定义“成功”，我们需要更好地了解癌症。正如孙子在他的名著《孙子兵法》中所指出的那样，赢得战斗需要知己知彼。尼克松总统宣布向癌症宣战，即1971年签署了《国家癌症法》，使癌症成为我们的敌人。这个敌人来自我们自己的细胞，不幸的是，它既是闪避的，又是进化的，因此赢得战斗变得复杂。了解自己意味着了解我们目前在抗癌药物输送方面的技术。我们编辑这本书的目的之一是更清楚地定义我们的敌人，并更好地了解我们自己的靶向药物输送能力。
Cancer is something that nobody welcomes. Yet, it visits us randomly. Once cancer shows up on our doorstep, it just won’t go away. It would be nice if we can figure out why and when cancer decides to visit any one of us. Cancer treatment has become more effective over the years, at least for some cancers, but overall cancer is seldom curable. Developing new effective drugs is important, but most drugs have side effects. The drug is useful as long as the benefit is larger than the side effects, but having the drug without side effects is the ultimate goal. One of the functions of drug delivery systems is to minimize the side effects while maximizing the pharmacological efficacy.While current drug delivery systems have shown promising results in increasing the benefit/risk ratio, the technology has to be improved substantially. Thus, we ask a simple, yet fundamental, question: why is it so difficult to cure cancer? Cancer is not a single disease that can be eradicated by a single drug. Cancer occurs for a variety of reasons and no two cancers are identical. To improve our chances of treating cancers successfully, depending on how we define “successful,” we need to understand cancer better. As Sun Tzu pointed out in his famous book, The Art of War, winning the battles requires knowing the enemy and ourselves. President Nixon declared the war on cancer, ie, signed the National Cancer Act, in 1971, making cancer our enemy. This enemy is derived from our own cells, and unfortunately, is evasive as well as evolving; thus winning the battle becomes complicated. To know ourselves means knowing our current technologies on delivery of anticancer agents. One of our goals of editing this book was to define our enemy more clearly and understand our own ability of targeted drug delivery better.