Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons
Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons
复制标题
DOI：
10.1002/hipo.20175
复制
发表时间：
2006-01-01
期刊：
影响因子：
3.5
通讯作者：
Trejo, JL
中科院分区：
文献类型：
--
作者：
Llorens-Martín, M;Torres-Alemán, I;Trejo, JL
在成年海马体中，神经发生既受到外部刺激（如体育锻炼）的影响，也受到内在条件（如年龄和疾病）的影响。然而，这些外部和内部线索在这一过程中相互作用的方式仍然知之甚少。我们使用了一种新的，更精确的，体视学细胞计数方法，包括共聚焦显微镜分析运动对小鼠成年神经发生的影响。我们发现，跑步机运动增加了小鼠海马颗粒细胞层中分化神经元（doublecortin/calretinin细胞）的数量，其方式与成熟颗粒细胞群的大小直接相关。运动后，在具有较大齿状回（DG）的动物中发现了更多的未成熟神经元，而在具有较小DG的动物中没有观察到变化。这种对体育锻炼的不同反应表明，预先存在的神经元群体调节DG对外部刺激的神经源性反应。这些数据提高了预测个体对旨在增强齿状神经发生和缓解或预防认知衰退的治疗干预（如运动）的反应的可能性。(c)2006威利-利斯公司
In the adult hippocampus, neurogenesis is influenced both by external stimuli, such as physical exercise, and by intrinsic conditions like age and disease. However, the way in which many of these external and internal cues interact in this process remains poorly understood. We have used a new, more precise, stereological cell counting method that involves confocal microscopy to analyze the effects of exercise on adult neurogenesis in the mouse. We found that treadmill exercise increases the number of differentiating neurons (doublecortin/calretinin cells) in the granule cell layer of the mouse hippocampus in a manner that is directly related to the size of the mature granule cell population. More immature neurons were found after exercise in animals that had a larger dentate gyrus (DG), while no changes were observed in those with a smaller DG. This differential response to physical exercise suggests that the pre-existing neuronal population regulates the neurogenic response in the DG to external stimuli. These data raise the possibility of anticipating an individuals' response to therapeutic interventions (like exercise) aimed at augmenting dentate neurogenesis and alleviating or preventing cognitive decline. (c) 2006 Wiley-Liss, Inc.