ETIOPATHOGENESIS OF THE RHEUMATOID ARTHRITIS-LIKE DISEASE IN MRL/1 MICE .1. THE HISTOMORPHOLOGIC BASIS OF JOINT DESTRUCTION
ETIOPATHOGENESIS OF THE RHEUMATOID ARTHRITIS-LIKE DISEASE IN MRL/1 MICE .1. THE HISTOMORPHOLOGIC BASIS OF JOINT DESTRUCTION
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DOI：
10.1002/art.1780280511
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
KOOPMAN, WJ
中科院分区：
文献类型：
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作者：
OSULLIVAN, FX;FASSBENDER, HG;KOOPMAN, WJ
MRL/L小鼠自发地出现后肢关节病和一些免疫异常，包括循环中的类风湿因子。虽然以前的研究表明这种关节病变主要是炎症过程，但进行了全面的组织形态学研究，表明炎症是MRL/L关节炎的晚期表现。这些小鼠关节的病理变化可分为3个阶段。第一阶段发育于7~13周龄，由关节隐窝内滑膜细胞增殖组成。第二阶段以滑膜细胞持续增殖为特征，其外观与转化的间充质细胞相似。最早的破坏性改变发生在第二阶段，包括边缘侵蚀，随后不久关节和半月板软骨逐渐破坏。末期滑膜细胞增殖减弱，软骨广泛破坏，形成瘢痕组织和纤维软骨，单核和多形核炎性细胞对滑膜基质的浸润度极低。在整个疾病发展过程中，炎性细胞渗出或渗出与组织破坏之间存在着明显的分离。人类风湿性滑膜炎与MRL/L小鼠关节炎在组织形态上的相似性以及类风湿因子的存在使该小鼠株成为研究人类类风湿关节炎的良好模型。
MRL/l mice spontaneously develop a hindlimb arthropathy and a number of immunologic abnormalities, including circulating rheumatoid factors. Although previous studies suggested that this arthropathy is primarily an inflammatory process, a comprehensive histomorphologic study was performed which indicated that inflammation is a late manifestation of MRL/l arthritis. The pathologic changes that occur in the joints of these mice can be divided into 3 stages. The 1st stage develops between the ages of 7 and 13 wk and consists of synovial cell proliferation in joint recesses. The 2nd stage is characterized by continued proliferation of synovial cells which take on an appearance similar to that of transformed mesenchymal cells. The earliest destructive changes occur in the 2nd stage and include marginal erosions, followed soon after by progressive destruction of articular and meniscal cartilage. The final stage is characterized by a diminution of synovial cell proliferation, extensive cartilage destruction, formation of scar tissue and fibrocartilage and a very moderate infiltration of the synovial stroma by mononuclear and polymorphonuclear inflammatory cells. Throughout the disease progression there is a striking dissociation between inflammatory cell infiltration or exudation and tissue destruction. The histomorphologic similarities between human rheumatoid synovitis and the arthritis of MRL/l mice and the presence of rheumatoid factors make this mouse strain an excellent model for studying human rheumatoid arthritis.