Postinspiratory mixing in the lung and cardiogenic oscillations.
Postinspiratory mixing in the lung and cardiogenic oscillations.
复制标题
肺中的吸气后混合和心源性振荡。
DOI：
10.1152/jappl.1981.51.4.922
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
VanLiew,HD
中科院分区：
文献类型：
--
作者：
Arieli,R;Olszowka,AJ;VanLiew,HD
受试者吸入 300 毫升指示气体混合物（SF6、Ar、Ne 和 He 各占 5%）以形成残余容量 (RV)，然后吸入空气至功能残余容量 (FRC)。没有证据表明 10 秒屏气会改变呼气第三阶段和第四阶段指示气体的相对浓度或数量，或允许额外的气体混合到 RV 中，但屏气会导致呼出气体中的心源性振荡 (CO) 高度降低。负责心源性波谷和波峰的单元分别与负责阶段 III 和 IV 的单元不同，因为振荡波谷具有比波峰更低的 He/SF6 比率，而阶段 III 具有比阶段 IV 更高的 He/SF6 比率。我们将 CO 解释为由于机械性能的变化，导致对心脏引起的压力波的响应发生变化，单位彼此相对接近。我们的结论是，远处的肺单位之间很少或没有吸气后混合，但 CO 的抑制表明，如果时间允许，彼此靠近的单位可以混合。
Subjects inspired a 300-ml bolus of indicator gas cocktail (5% each of SF6, Ar, Ne, and He) form residual volume (RV), then inspired air to functional residual capacity (FRC). There was no evidence that a 10-s breath hold changed the relative concentrations or amounts of indicator gases in phases III and IV of expiration or allowed additional gas to mix into the RV, but the breath hold caused cardiogenic oscillations (CO) in expired gas to decrease in height. The units responsible for cardiogenic troughs and peaks are different from the units responsible for phases III and IV, respectively, in that the oscillation troughs had a lower He/SF6 ratio than the peaks whereas phase III had a higher He/SF6 than phase IV. We explain the CO as due to variation in mechanical properties, leading to variation in response to the pressure wave caused by the heart, in units that are relatively near to each other. We conclude that there is little or no postinspiratory mixing between distant lung units, but the dampening of CO suggests that units that are close to each other can mix if time is allowed.