Familial prevalence of uterine fibroids is associated with distinct clinical and molecular features
Familial prevalence of uterine fibroids is associated with distinct clinical and molecular features
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DOI：
10.1093/humrep/dei049
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发表时间：
2005-08-01
影响因子：
6.1
通讯作者：
Maclean, AB
中科院分区：
文献类型：
--
作者：
Okolo, SO;Gentry, CC;Maclean, AB
背景：虽然子宫肌瘤很常见，但其发病机制和临床表现知之甚少。由于它们可能在某些家庭中流行，我们调查了这种流行是否与独特的临床和分子特征有关。方法：采用正交设计法对伦敦大学医院300例多种族子宫肌瘤妇女进行了病例对照问卷调查研究，回顾了病例记录和子宫肌瘤血管内皮生长因子（VEGF-A）的免疫组化测定。研究结果：与散发性子宫肌瘤家族相比，子宫肌瘤家族患病率与腹部肿胀的发生率较高相关（59.1% vs 41.6%; P=0.037），月经过多（84.4% vs 51.9%; P=0.042），排尿困难（64.4%对46.3%; P=0.004）、性交困难（43.2%对27.9%; P=0.012）和癌症家族史（52.3%对32.4%; P < 0.01）。肌瘤也更多发（平均值+/- SEM：7 +/- 0.86对3 +/- 0.42; P < 0.011），并且肌瘤中的强VEGF-A表达在家族性组中更常见（64%对28%）。两组的种族分布相同（黑人49%，白人33.4%，其他18.6%）。结论：子宫肌瘤的家族患病率与不同的临床和分子特征相关，这些特征不同于家族中零星发生的子宫肌瘤。
BACKGROUND: Although uterine fibroids are very common, their pathogenesis and clinical behaviour are poorly understood. Since they may be prevalent in some families, we investigated whether such a prevalence was associated with distinctive clinical and molecular features. METHODS: A case-control questionnaire study of 300 multi-ethnic women with uterine fibroids at a London university hospital was undertaken, with review of case notes and immunohistochemical determination of vascular endothelial growth factor (VEGF-A) in fibroids. RESULTS: When compared with families with sporadic fibroids, familial prevalence of fibroids was associated with a higher incidence of abdominal swelling (59.1% versus 41.6%; P=0.037), menorrhagia (84.4% versus 51.9%; P=0.042), dysmenorrhoea (64.4% versus 46.3%; P=0.004), dyspareunia (43.2% versus 27.9%; P=0.012) and family history of cancers (52.3% versus 32.4%; P < 0.01). The fibroids were also more multiple (mean +/- SEM: 7 +/- 0.86 versus 3 +/- 0.42; P < 0.011) and strong VEGF-A expression in fibroids was more common in the familial group (64% versus 28%). Racial distribution was the same in both groups (blacks 49%, whites 33.4%, others 18.6%). CONCLUSIONS: Familial prevalence of uterine fibroids is associated with distinct clinical and molecular features that differ from those found when fibroids occur sporadically in families.