Superior limbic keratoconjunctivitis: multifactorial mechanical pathogenesis
Superior limbic keratoconjunctivitis: multifactorial mechanical pathogenesis
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DOI：
10.1046/j.1442-9071.2000.00284.x
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发表时间：
2000-06-01
影响因子：
4
通讯作者：
Cher, I
中科院分区：
文献类型：
--
作者：
Cher, I
上缘角膜结膜炎（SLK）的起源尚不清楚。受到压力和摩擦可能导致SLK的建议的启发，本文利用文献和个人柯达胶卷记录的证据，旨在评估并在适当的情况下加强这种理解。调查揭示了证实机械病因的证据。支持SLK起源于软组织微创伤的观点：(i)跗骨和球表面之间；结膜基质和巩膜之间。在每一对中，两个相对的组织彼此重复运动。由此得出结论，SLK的发生是因为多种易感因素和/或触发因素的非标准组合超过了眼表和组织对机械应力的生理耐受性。通过它们对特定组织的作用，可以感知到八种不同的应力。这四类因素被整合成一个新的病原学概念。
Origins of superior limbic keratoconjunctivitis (SLK) are not well understood. Prompted by suggestions that pressure and friction may contribute to SLK, this paper, using evidence from the literature and from personal Kodachrome records, aims to assess, and if appropriate, enhance this understanding. The survey disclosed evidence confirming mechanical aetiology. Support is presented for the notion that SLK arises from soft tissue microtrauma: (i) between tarsal and bulbar surfaces; and (ii) between conjunctival stroma and sclera. In each pair the two apposed tissues are in repetitive motion relative to each other. It is concluded that SLK arises because non-standard combinations of multiple predisposing and/or trigger factors exceed the physiological tolerance of mechanical stresses upon the ocular surface and tissues. Through their effects on particular tissues, eight separate stressing forces were perceived. The many contributing factors in four categories are integrated into a new aetiologic concept.