Effect of very-low-calorie diets with weight loss on obstructive sleep apnea.
Effect of very-low-calorie diets with weight loss on obstructive sleep apnea.
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DOI：
10.1093/ajcn/56.1.182s
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发表时间：
1992-07
期刊：
影响因子：
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通讯作者：
P. Suratt;R. McTier;L. Findley;S. Pohl;S. Wilhoit
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文献类型：
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作者：
P. Suratt;R. McTier;L. Findley;S. Pohl;S. Wilhoit
为了确定极低热量饮食 (VLCD) 结合减肥对阻塞性睡眠呼吸暂停 (OSA) 的影响，我们研究了八名患有 OSA 的肥胖受试者，其中五名男性和三名女性。受试者消耗了 1760 kJ（420 kcal）（67% 蛋白质、4% 脂肪、29% 碳水化合物）或 3350 kJ（800 cal）（20% 蛋白质、30% 脂肪、50% 碳水化合物）的 VLCD，以及 100% 每日推荐摄入量的维生素和矿物质。体重减轻前后体重和呼吸的平均（+/- SD）值分别为153 +/- 37和132 +/- 29 kg（P小于0.05）； BMI (kg/m2) 为 54 +/- 13 和 46 +/- 10（P 小于 0.05）；对于每小时睡眠去饱和度，106 +/- 50 和 52 +/- 45（P 小于 0.05）；对于呼吸暂停 + 呼吸不足/小时睡眠，90 +/- 32 和 62 +/- 49；对于 Pco2，48 +/- 10 和 42 +/- 4 托（P 小于 0.05）。六名患者的每小时去饱和次数和每小时呼吸暂停 + 呼吸不足有所改善。体重减轻最多（47 公斤）的最肥胖受试者（女性，BMI 81）没有改善，体重减轻最少（7 公斤）的受试者也没有改善。所有患者的运动+睡眠唤醒次数均减少（P 小于 0.05）。我们的结论是，VLCD 结合减肥可以改善 OSA；体重减轻少量的受试者或减肥前后极度肥胖的受试者可能不会改善。
To determine the effect of very-low-calorie diets (VLCDs) with weight loss on obstructive sleep apnea (OSA), we studied eight obese subjects with OSA, five males and three females. Subjects consumed a VLCD of 1760 kJ (420 kcal) (67% protein, 4% fat, 29% carbohydrate) or 3350 kJ (800 cal) (20% protein, 30% fat, 50% carbohydrate) with 100% of the recommended daily allowance of vitamins and minerals. Mean (+/- SD) values of weight and respiration before and after weight loss were, for weight, 153 +/- 37 and 132 +/- 29 kg (P less than 0.05); for BMI (kg/m2), 54 +/- 13 and 46 +/- 10 (P less than 0.05); for desaturations/h sleep, 106 +/- 50 and 52 +/- 45 (P less than 0.05); for apneas + hypopneas/h sleep, 90 +/- 32 and 62 +/- 49; for Pco2, 48 +/- 10 and 42 +/- 4 torr (P less than 0.05). Desaturation episodes/h and apnea + hypopneas/h improved in six patients. The most obese subject (female, BMI 81) who lost the most weight (47 kg) did not improve, nor did the subject who lost the least weight, 7 kg. The number of movements + arousals from sleep decreased in all patients (P less than 0.05). We conclude that VLCD with weight loss can produce improvement in OSA; subjects who lose a small amount of weight or subjects who are extraordinarily obese before and after weight loss may not improve.