COOLING OF NUCLEUS RAPHE DORSALIS INDUCES SLEEP IN CAT
COOLING OF NUCLEUS RAPHE DORSALIS INDUCES SLEEP IN CAT
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DOI：
10.1016/0304-3940(76)90077-x
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发表时间：
1976-01-01
影响因子：
2.5
通讯作者：
MUSOLINO, R
中科院分区：
文献类型：
--
作者：
CESPUGLIO, R;WALKER, E;MUSOLINO, R
中缝背侧前部和腹侧部分的局部中度冷却（+10°C）诱导皮质同步和桥膝枕叶（PGO）波，有时会导致反常睡眠。冷却中缝大核区域会产生皮质唤醒。对氯苯丙氨酸耗尽大脑 5-羟色胺 (5-HT) 后，中缝背侧冷却会导致肌肉无力和高频 PGO 波爆发，但不会导致皮质同步。通过静脉注射恢复大脑 5-HT 后与对照实验一样，给予 5-羟色氨酸后，冷却再次产生皮质同步和 PGO 波，但在重复冷却过程中功效逐渐减弱。
Localized moderate cooling (+10.degree. C) of the anterior and ventral part of the raphe dorsalis induced cortical synchronization and ponto-geniculo-occipital (PGO) waves followed sometimes by paradoxical sleep. Cooling the region of the raphe magnus produced cortical arousal. After depletion of brain 5-hydroxytryptamine (5-HT) by p-chlorophenylalanine, cooling the raphe dorsalis resulted in muscle atonia and bursts of high frequency PGO waves but not in cortical synchronization. Following restoration of brain 5-HT by i.v. administration of 5-hydroxytryptophan, cooling again produced cortical synchronization and PGO waves as in the control experiments, but with a diminishing efficacy during repetitive cooling episodes.