MULTIPLE PARAGANGLIONEUROMAS
MULTIPLE PARAGANGLIONEUROMAS
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DOI：
10.1007/bf00704306
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
GOSEKI, N
中科院分区：
文献类型：
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作者：
KAWAGUCHI, K;TAKIZAWA, T;GOSEKI, N
我们报告多发副神经节神经瘤发生在一个40岁的男人。32例具有相似组织学表现的肿瘤已被报道，其中大多数表现出明显的倾向于发生在十二指肠的第二部分。在这种情况下，检测到三个质量；一例位于十二指肠壶腹周围区域，呈息肉样样外观，另一例位于胰腺周围组织，靠近大血管。组织学显示两种细胞成分，具有NSE免疫反应性的上皮样细胞和含有S-100蛋白的梭形细胞。电镜下观察到三种不同类型的上皮样细胞。I型是向神经节细胞分化的图形，II型是向副神经节细胞分化的图形，III型是神经节细胞和副神经节细胞的杂交形式。副神经节神经瘤表现为神经节神经瘤、副神经节神经瘤及混合型。在这方面，肿瘤可能被认为起源于未分化的神经嵴细胞，并发展为类器官分化。
We report multiple paraganglioneuromas which occurred in a 40-year-old-man. Thirty-two tumours with similar histological appearance have been reported previously and most of them showed a striking predilection to occur in the second portion of the duodenum. In this case, three masses were detected; one was located in the periampullary region of duodenum with a polypoid appearance, the others were well defined masses in peri-pancreatic tissue adjacent to large vessels. Histology revealed two cellular components, epithelioid cells with NSE immunoreactivity and S-100 protein containing spindle-shaped cells. Moreover, on electron microscopical examination, three different epithelioid cell types were seen. Type I was a figure differentiating to ganglion cells, type II to paraganglion cells, type III was a hybrid form of ganglion and paraganglion cells. Paraganglioneuroma revealed the histopathology of ganglioneuroma, paraganglioma and also a mixed appearance. In this respect the tumour may be considered to originate in undifferentiated neural crest cells and develop organoid differentiation.