Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change Modeling.
Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change Modeling.
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DOI：
10.1289/ehp7305
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发表时间：
2021-01
影响因子：
10.4
通讯作者：
Wyrwoll CS
中科院分区：
文献类型：
--
作者：
Larcombe AN;Papini MG;Chivers EK;Berry LJ;Lucas RM;Wyrwoll CS
气候变化模式预测，在未来80年内，大气中的二氧化碳[]水平将在百万分之700至900之间。尽管如此，暴露于轻度升高的大气（与今天的经验相比）的直接生理影响，特别是暴露于从孕前到成年期的直接生理影响尚未得到彻底研究。在这项研究中，我们旨在通过小鼠模型评估从孕前到成年期长期暴露于呼吸结构和功能的影响。我们将小鼠暴露于（）中，从怀孕前，到子宫内和生命早期，直到3个月大，在这一点上，我们使用强迫振荡技术评估呼吸功能和肺结构。暴露导致一系列呼吸损伤，尤其是雌性小鼠，包括更高的组织弹性、更长的弦长和更低的肺顺应性。重要的是，我们还评估了生下实验对象的母鼠的肺功能。即使这些小鼠暴露于相同水平的增加的时间相似（），我们也没有测量到肺功能的损害。这表明，在生命早期，当肺部正在经历快速生长和发育时，对其特别敏感。据我们所知，这项研究首次表明，长期暴露于与环境相关的水平会影响小鼠的呼吸功能。https://doi.org/10.1289/EHP7305
Climate change models predict that atmospheric carbon dioxide [] levels will be between 700 and 900 ppm within the next 80 y. Despite this, the direct physiological effects of exposure to slightly elevated atmospheric (as compared with experienced today), especially when exposures extend from preconception to adulthood, have not been thoroughly studied. In this study we aimed to assess the respiratory structure and function effects of long-term exposure to from preconception to adulthood using a mouse model. We exposed mice to () from prepregnancy, through the in utero and early life periods, until 3 months of age, at which point we assessed respiratory function using the forced oscillation technique, and lung structure. exposure resulted in a range of respiratory impairments, particularly in female mice, including higher tissue elastance, longer chord length, and lower lung compliance. Importantly, we also assessed the lung function of the dams that gave birth to our experimental subjects. Even though these mice had been exposed to the same level of increased for a similar amount of time (), we measured no impairments in lung function. This suggests that the early life period, when lungs are undergoing rapid growth and development, is particularly sensitive to . To the best of our knowledge, this study, for the first time, shows that long-term exposure to environmentally relevant levels of can impact respiratory function in the mouse. https://doi.org/10.1289/EHP7305