Derivation of vascular wall shear stress from 1000 fps high-speed angiography (HSA) velocity distributions.
Derivation of vascular wall shear stress from 1000 fps high-speed angiography (HSA) velocity distributions.
复制标题
从 1000 fps 高速血管造影 (HSA) 速度分布推导血管壁剪切应力。
DOI：
10.1117/12.2611175
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Rudin,S
中科院分区：
文献类型：
--
作者：
Shields,A;SetlurNagesh,SV;Chivukula,V;Ionita,C;Bednarek,DR;Rudin,S
血流的病理变化导致血流动力学改变，从而导致与脉管系统重塑和再生相关的许多病症。更具体地说，壁剪切应力（WSS）已被证明是与动脉瘤生长和破裂以及导致中风风险增加的斑块激活相关的重要血流动力学参数。由于对壁边界附近的空间分辨率有严格的要求，以及与壁上通常假设的抛物线流动行为的偏差，剪切应力的体内测量很困难。在这项工作中，我们提出了一种根据高时间分辨率速度分布进行体外 WSS 计算的实验方法，这些速度分布源自 1000 fps 高速血管造影 (HSA)。我们的 HSA 探测器具有高空间和时间分辨率，使得这种高分辨率速度梯度测量成为可能。这里介绍的是成像平面中 WSS 的计算方法，以及生理学实际流速下各种血管几何形状的初始结果。此外，使用 CFD 导出的速度数据探讨了空间分辨率对梯度计算的影响。这种基于 HSA 的血管造影分析有可能在介入环境中提供关键的血流动力学反馈，其总体目标是支持临床决策和改善患者的治疗结果。
Pathological changes in blood flow lead to altered hemodynamic forces, which are responsible for a number of conditions related to the remodeling and regeneration of the vasculature. More specifically, wall shear stress (WSS) has been shown to be a significant hemodynamic parameter with respect to aneurysm growth and rupture, as well as plaque activation leading to increased risk of stroke. In-vivo measurement of shear stress is difficult due to the stringent requirements on spatial resolution near the wall boundaries, as well as the deviation from the commonly assumed parabolic flow behavior at the wall. In this work, we propose an experimental method of in-vitro WSS calculations from high-temporal resolution velocity distributions, which are derived from 1000 fps high-speed angiography (HSA). The high-spatial and temporal resolution of our HSA detector makes such high-resolution velocity gradient measurements feasible. Presented here is the methodology for calculation of WSS in the imaging plane, as well as initial results for a variety of vascular geometries at physiologically realistic flow rates. Further, the effect of spatial resolution on the gradient calculation is explored using CFD-derived velocity data. Such angiographic-based analysis with HSA has the potential to provide critical hemodynamic feedback in an interventional setting, with the overarching objective of supporting clinical decision-making and improving patient outcomes.