A case of autoimmune hypoglycemia outside Japan: Rare, but in the era of expanding drug-list, important to suspect
A case of autoimmune hypoglycemia outside Japan: Rare, but in the era of expanding drug-list, important to suspect
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日本以外的自身免疫性低血糖病例：罕见，但在药物清单不断扩大的时代，值得怀疑
DOI：
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发表时间：
2013
影响因子：
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通讯作者：
R. Khadgawat
中科院分区：
文献类型：
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作者：
Krishan Gopal;G. Priya;N. Gupta;E. P. Praveen;R. Khadgawat
我们在此报告一例72岁的印度男性，在没有可检测到的肿瘤的情况下，在吸收后状态（餐后3-5小时）出现症状性低血糖。他的血清胰岛素和C肽水平非常高。他没有服用任何降血糖药物。停用戊妥拉唑并在饮食计划中加入少量频繁进餐后，低血糖发作完全消退。首次就诊后6个月，受试者未发生低血糖发作。虽然胰岛素自身免疫综合征（IAS）在日本是自发性低血糖的第三大原因，但在西方国家却极为罕见。截至2009年，日本报告了200多例病例，亚洲以外报告了多达58例病例。据我们所知，这是印度报告的第一例IAS。
We are hereby reporting a case of a 72-year-old Indian man, who, in the absence of a detectable tumor, presented with symptomatic hypoglycemia in the postabsorptive state (3-5 h after meal). His serum levels of insulin and C-peptide were very high. He was not taking any hypoglycemic drug. Hypoglycemic episodes completely subsided after withdrawal of pentoprazole and incorporation of small frequent meals in the dietary plan. Six months after the initial presentation, the subject became free of hypoglycemic episodes. Although insulin autoimmune syndrome (IAS) is the third leading cause of spontaneous hypoglycemia in Japan, it is extremely uncommon in the Western Countries. Till 2009, more than 200 cases from Japan and as many as 58 cases outside Asia have been reported. To the best of our knowledge, this is the first case of IAS reported from India.