Decreased peripheral dopaminergic activity in essential hypertension?
Decreased peripheral dopaminergic activity in essential hypertension?
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原发性高血压患者外周多巴胺能活性降低？
DOI：
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发表时间：
1983
影响因子：
2.1
通讯作者：
E. Fønstelien
中科院分区：
文献类型：
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作者：
S. Kjeldsen;B. Flaaten;I. Eide;A. Helgeland;P. Leren;E. Fønstelien
42例年龄为50±1岁未经治疗的持续性高血压患者和34例年龄匹配的正常血压男性患者立位时静脉血中游离多巴胺浓度高于仰卧位60%以上，提示多巴胺参与了立位反应。在高血压组和正常血压组，仰卧位动脉血浆多巴胺浓度均显著高于静脉仰卧位(P<0.004)，表明这种儿茶酚胺是从大脑、肾脏或肾上腺等中枢器官释放出来的。高血压组的静脉仰卧位、动静脉立位血浆多巴胺浓度及尿儿茶酚胺排泄量均低于正常血压组。两组间静脉多巴胺浓度差异有统计学意义(P<0.04)，当静脉仰卧位、动脉血和站立血浆浓度加在一起时，两组间差异有统计学意义(P<0.03)。这一发现可能表明高血压患者外周血中多巴胺能活性降低。
In 42 men aged 50 +/- 1 years with untreated, sustained essential hypertension and in 34 age-matched normotensive men plasma free dopamine concentrations in venous blood in the standing position were more than 60% higher than supine values indicating dopamine involvement in the orthostatic response. In both the hypertensive and normotensive group supine arterial plasma dopamine concentrations were significantly higher than venous supine (P less than 0.004) indicating release of this catecholamine from central organs such as brain, kidneys or adrenals. In the hypertensive group both venous supine, arterial and venous standing plasma dopamine concentrations and the urinary excretion of this catecholamine were lower than in the normotensive group. Between the groups, statistical significance was achieved for venous standing dopamine concentrations (P less than 0.04) and when venous supine, arterial and standing plasma concentrations were added together for each individual (P less than 0.03). The findings may indicate decreased peripheral dopaminergic activity in patients with essential hypertension.