Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons
Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons
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DOI：
10.1038/nn.4062
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发表时间：
2015-08-01
影响因子：
25
通讯作者：
Magee, Jeffrey C.
中科院分区：
文献类型：
--
作者：
Bittner, Katie C.;Grienberger, Christine;Magee, Jeffrey C.
选择性放电使网络能够产生外部和内部环境的表征。尽管其重要性，产生神经元特征选择性的机制是不完全理解的。在许多皮层微电路中，两个功能不同的输入的整合通过产生驱动突发放电和鲁棒可塑性的活性树突信号而非线性地发生。为了研究这种处理在特征选择性中的作用，我们记录了在线性跑步机上跑步的小鼠的CA1锥体神经元膜电位和局部场电位。我们发现，树突平台电位产生的相互作用，适当定时输入从内嗅皮层和海马CA3。这些合取信号积极调制发射先前建立的地方字段，并迅速诱导新的地方字段的形成，以产生功能的选择性在CA1，这是一个功能的内嗅皮层和CA3输入。这种选择性可以允许支持上下文相关的空间地图的混合网络级表示。
Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct inputs occurs nonlinearly through generation of active dendritic signals that drive burst firing and robust plasticity. To examine the role of this processing in feature selectivity, we recorded CA1 pyramidal neuron membrane potential and local field potential in mice running on a linear treadmill. We found that dendritic plateau potentials were produced by an interaction between properly timed input from entorhinal cortex and hippocampal CA3. These conjunctive signals positively modulated the firing of previously established place fields and rapidly induced new place field formation to produce feature selectivity in CA1 that is a function of both entorhinal cortex and CA3 input. Such selectivity could allow mixed network level representations that support context-dependent spatial maps.