Bone marrow transplantation in Shwachman–Diamond syndrome: report of two cases and review of the literature
Bone marrow transplantation in Shwachman–Diamond syndrome: report of two cases and review of the literature
复制标题
骨髓移植治疗Shwachman-Diamond综合征二例报告及文献复习
作者：
F. Okcu;W. Roberts;Kw Chan
Shwachman-Diamond综合征(SDS)患者骨髓发育不良和白血病转化的频率增加。我们描述了两名接受异基因干细胞移植的患者，他们出现了多种并发症，包括癫痫、高血糖和肾小管酸中毒。对文献的回顾表明，患有抑郁症的患者似乎有更高的各种移植相关问题的发生率。这些患者经常有潜在的器官功能障碍，在接受异基因干细胞移植治疗时应极其谨慎。
Patients with Shwachman–Diamond syndrome (SDS) have an increased frequency of myelodysplasia and leukemic transformation. We described two patients who received allogeneic stem cell transplantation and developed multiple complications, including seizure, hyperglycemia and renal tubular acidosis. A review of the literature showed that patients with SDS appeared to have an increased incidence of various transplant-associated problems. These patients frequently have underlying organ dysfunction and should be managed with extreme caution when treated with allogeneic stem cell transplantation.
一名患有 Shwachman-Diamond 综合征和严重骨髓衰竭的 10 岁男孩因环磷酰胺诱发致命性充血性心力衰竭，接受同种异体骨髓移植治疗。
DOI：
10.1097/00043426-199024000-00012
发表时间：
1990
期刊：
The American journal of pediatric hematology/oncology
影响因子：
--
作者：
Tsai,PH;Sahdev,I;Herry,A;Lipton,JM
通讯作者：
Lipton,JM