Three-dimensional tonotopic organization of the C57 mouse cochlear nucleus
Three-dimensional tonotopic organization of the C57 mouse cochlear nucleus
复制标题
DOI：
10.1016/j.heares.2009.08.002
复制
发表时间：
2009-11-01
期刊：
影响因子：
2.8
通讯作者：
Yan, Jun
中科院分区：
文献类型：
--
作者：
Luo, Feng;Wang, Qianzhou;Yan, Jun
耳蜗核（CN）是中央听觉系统的第一个声音处理中心，接收来自听觉外周的几乎未经处理的听觉信息。在许多哺乳动物中，包括猫、鼠和蝙蝠，对CN的功能组织进行了大量的研究。然而，尽管小鼠的一般用途，包括各种近交系和基因操纵系的可用性，我们目前对小鼠CN的理解仍然有限。本研究的目的是利用电生理方法阐明C57小鼠CN的功能组织。我们的研究结果表明，在所有三个CN细分中，CN神经元的听觉反应特性是相似的。声频系统地代表了三个CN细分，即前腹、后腹和背侧。CN神经元的最佳频率沿背medial-to-腹外侧轴呈有序的递减趋势，而在背侧面，其异位轴相对不明显。在CN的每个细分内，没有拓扑图的中断。研究结果表明，C57小鼠的CN异位组织与猫和其他哺乳动物相似。(C) 2009 Elsevier B.V.版权所有
The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the general usefulness of the mouse, including the availability of various inbred strains and gene-manipulated lines, our current understanding of the mouse CN remains limited. The purpose of this study was to illustrate the functional organization of the CN in C57 mice, using an electrophysiological approach. Our results showed that the auditory response properties of CN neurons were similar in all three of the CN subdivisions. Sound frequency was systematically represented in each of the three CN subdivisions, i.e., the anteroventral, posteroventral and the dorsal divisions. The best frequency of CN neurons decreased along the dorsomedial-to-ventrolateral axis in an orderly progression whereas the tonotopic axes were relatively indistinct in the rostrocaudal plane. There was no disruption of the tonotopic map within each subdivision of the CN. The findings indicate, that the CN tonotopic organization in the C57 mouse is similar to that in the cat and other mammals. (C) 2009 Elsevier B.V. All rights reserved.