Endothelin-3 can both facilitate and inhibit transmitter release in the guinea-pig vas deferens.
Endothelin-3 can both facilitate and inhibit transmitter release in the guinea-pig vas deferens.
复制标题
Endothelin-3 既可以促进也可以抑制豚鼠输精管中递质的释放。
DOI：
10.1016/0014-2999(95)00501-b
复制
发表时间：
1995
影响因子：
5
通讯作者：
Westfall,DP
中科院分区：
文献类型：
--
作者：
Mutafova-Yambolieva,VN;Westfall,DP
Endothelin-3 (10 nM) produced a significant facilitation of the release of ATP from the in vitro guinea-pig vas deferens. This effect was converted to an inhibition of release by pretreatment with BQ-123, cyclo-(d-Trp,d-Asp,l-Pro,d-Val,l-Leu), an endothelin ETAreceptor antagonist. Desensitization of endothelin ETBreceptors by sarafotoxin S6c antagonized, but did not reverse, the facilitatory effect of endothelin-3. The release of noradrenaline was not facilitated by endothelin-3; however, following pretreatment with BQ-123 the release of noradrenaline was reduced by the peptide. These results indicate that there may be both facilitatory and inhibitory prejunctional endothelin receptors and further suggest that the release of the sympathetic nerve cotransmitters ATP and noradrenaline may be differentially modulated.
