Transcortical descending pathways through granular insular cortex conveying orofacial proprioception
Transcortical descending pathways through granular insular cortex conveying orofacial proprioception
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通过粒状岛叶皮层传递口面本体感觉的经皮层下行通路
DOI：
10.1016/j.brainres.2018.02.033
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Yoshida Atsushi
中科院分区：
文献类型：
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作者：
Ikenoue Etsuko;Akhter Fatema;Tsutsumi Yumi;Sato Fumihiko;Ohara Haruka;Uchino Katsuro;Furuta Takahiro;Tachibana Yoshihisa;Yoshida Atsushi
我们的运动行为可能会受到本体感受信息的影响。然而，我们对哪些大脑回路参与这一过程知之甚少。我们最近发现，闭颌肌梭（JCMS）产生的本体感觉信息通过三叉神经中脑核（Me5）中的神经元传递到三叉上核（Su5），然后传递到丘脑腹后内侧核（VPMcvm）的尾腹内侧缘，最后传递到丘脑腹后内侧核（VPMcvm）。 粒状岛叶皮层的背侧部分与次级体感皮层（dGIrvs2）的最前端部分相邻。我们的下一个问题是哪些大脑区域接收来自 dGIrvs2 的下颌运动信息。为了测试这个问题，我们将顺行示踪剂生物素化右旋糖胺注射到 dGIrvs2 中，并分析了标记的轴突末端的分布概况。顺行标记的轴突分布在脑桥延髓区域（包括 Su5），已知该区域接收由 Me5 神经元直接传递的 JCMS 本体感受输入，并包含投射到三叉神经运动核（Mo5）中的下颌闭合运动神经元的前运动神经元。在 VPMcvm 内部和周围也发现了它们。相反，在 Me5 神经元和 Mo5 运动神经元的细胞体上没有检测到标记的轴突末端。这些数据表明，由源自外周 JCMS 本体感觉信息的经典定义的下颌反射弧引起的下颌运动也可以通过从 dGIrvs2 到 VPMcvm 和 Su5 的跨皮质反馈连接来调节。
Our motor behavior can be affected by proprioceptive information. However, little is known about which brain circuits contribute to this process. We have recently revealed that the proprioceptive information arising from jaw-closing muscle spindles (JCMSs) is conveyed to the supratrigeminal nucleus (Su5) by neurons in the trigeminal mesencephalic nucleus (Me5), then to the caudo-ventromedial edge of ventral posteromedial thalamic nucleus (VPMcvm), and finally to the dorsal part of granular insular cortex rostroventrally adjacent to the rostralmost part of secondary somatosensory cortex (dGIrvs2). Our next question is which brain areas receive the information from the dGIrvs2 for the jaw-movements. To test this issue, we injected an anterograde tracer, biotinylated dextranamine, into the dGIrvs2, and analyzed the resultant distribution profiles of the labeled axon terminals. Anterogradely labeled axons were distributed in the pontomedullary areas (including the Su5) which are known to receive JCMS proprioceptive inputs conveyed directly by the Me5 neurons and to contain premotoneurons projecting to the jaw-closing motoneurons in the trigeminal motor nucleus (Mo5). They were also found in and around the VPMcvm. In contrast, no labeled axonal terminals were detected on the cell bodies of Me5 neurons and motoneurons in the Mo5. These data suggest that jaw-movements, which are evoked by the classically defined jaw-reflex arc originating from the peripheral JCMS proprioceptive information, could also be modulated by the transcortical feedback connections from the dGIrvs2 to the VPMcvm and Su5.