Pacifier Cleaning Practices and Risk of Allergy Development
Pacifier Cleaning Practices and Risk of Allergy Development
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DOI：
10.1542/peds.2012-3345
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发表时间：
2013-06-01
期刊：
影响因子：
8
通讯作者：
Wold, Agnes E.
中科院分区：
文献类型：
--
作者：
Hesselmar, Bill;Sjoberg, Fei;Wold, Agnes E.
目的：通过暴露于肠道微生物的免疫刺激可以防止过敏的发展。口腔微生物可以通过奶嘴从父母转移到婴儿。我们调查了奶嘴清洁的做法是否影响过敏development.METHODS的风险：出生队列的184名婴儿进行了检查，在18个月和36个月的年龄，临床过敏和致敏空气和食物过敏原，此外，及时出现症状。当孩子6个月大时，在与父母的访谈中记录了使用奶嘴和清洁奶嘴的做法。通过对4个月大时收集的唾液样本进行分析，对婴儿的口腔微生物群进行表征。结果：父母通过吸吮奶嘴来“清洁”奶嘴的儿童（n = 65）患哮喘的可能性较小（比值比[OR] 0.12; 95%置信区间[CI] 0.01-0.99），湿疹（OR 0.37; 95% CI 0.15-0.91）和致敏（OR 0.37; 95% CI 0.10-1.27）在18个月龄时比父母不使用这种清洁技术的儿童（n = 58）。对湿疹的保护作用在36个月时仍然存在（风险比0.51; P = 0.04）。阴道分娩和父母奶嘴吸吮产生了独立的和附加的保护作用，对湿疹的发展。唾液微生物群不同的儿童的父母清洁他们的奶嘴吸吮它和儿童的父母没有使用这种practice.CONCLUSIONS：父母吸吮他们的婴儿的奶嘴可能会降低过敏发展的风险，可能通过免疫刺激的微生物转移到婴儿通过父母的唾液。
OBJECTIVE: Immune stimulation through exposure to commensal microbes may protect against allergy development. Oral microbes may be transferred from parents to infants via pacifiers. We investigated whether pacifier cleaning practices affected the risk of allergy development.METHODS: A birth-cohort of 184 infants was examined for clinical allergy and sensitization to airborne and food allergens at 18 and 36 months of age and, in addition, promptly on occurrence of symptoms. Pacifier use and pacifier cleaning practices were recorded during interviews with the parents when the children were 6 months old. The oral microbiota of the infants was characterized by analysis of saliva samples collected at 4 months of age.RESULTS: Children whose parents "cleaned" their pacifier by sucking it (n = 65) were less likely to have asthma (odds ratio [OR] 0.12; 95% confidence interval [CI] 0.01-0.99), eczema (OR 0.37; 95% CI 0.15-0.91), and sensitization (OR 0.37; 95% CI 0.10-1.27) at 18 months of age than children whose parents did not use this cleaning technique (n = 58). Protection against eczema remained at age 36 months (hazard ratio 0.51; P = .04). Vaginal delivery and parental pacifier sucking yielded independent and additive protective effects against eczema development. The salivary microbiota differed between children whose parents cleaned their pacifier by sucking it and children whose parents did not use this practice.CONCLUSIONS: Parental sucking of their infant's pacifier may reduce the risk of allergy development, possibly via immune stimulation by microbes transferred to the infant via the parent's saliva.