Acute hemorrhagic pancreatic necrosis produced by local Shwartzman reaction: experimental study on pancreatitis.
Acute hemorrhagic pancreatic necrosis produced by local Shwartzman reaction: experimental study on pancreatitis.
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局部Shwartzman反应引起的急性出血性胰腺坏死：胰腺炎的实验研究。
DOI：
10.1001/jama.1954.73690240003011
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发表时间：
1954
影响因子：
--
通讯作者：
E. Brackney
中科院分区：
文献类型：
--
作者：
A. Thal;E. Brackney
致死性出血性胰腺坏死病例的组织学观察一致显示广泛的血管损伤。这些病变从弥漫性透明毛细血管血栓形成到小动脉、小静脉和大血管广泛坏死不等。1常伴有出血、血栓形成和炎性细胞浸润。血管病变是否是暴露于释放的胰蛋白酶的结果，或者确实是产生出血性胰腺炎的主要因素，目前尚不清楚。在研究皮肤Shwartzman反应时，很明显，这种快速发展的血管病变与急性出血性胰腺炎之间有惊人的相似性。因此，本研究的目的是评估原发性血管致敏在出血性胰腺炎发病机制中的作用。本文报道的实验证明了胰腺导管系统对在生理压力范围内灌注的细菌产物的渗透性以及这些产物使胰腺血液敏感的能力
Histological observations in cases of fatal hemorrhagic pancreatic necrosis consistently show extensive vascular injury. These lesions vary from diffuse hyaline capillary thrombosis to extensive necrosis of arterioles, venules, and larger vessels.1Frequently there is accompanying hemorrhage, thrombosis, and inflammatory cell infiltration. Whether the vascular lesion is the result of exposure to liberated trypsin or is, indeed, the primary factor producing hemorrhagic pancreatitis is not yet clear.1b In studying the dermal Shwartzman reaction it became apparent that there was a striking similarity between this rapidly developing vascular lesion and that of acute hemorrhagic pancreatitis. Accordingly, the present study was undertaken with the object of evaluating the role of primary vascular sensitization in the pathogenesis of hemorrhagic pancreatitis. The experiments herein reported demonstrate the permeability of the pancreatic ductal system to bacterial products perfused within the physiological pressure range and the ability of such products to sensitize the pancreatic blood