(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones:: Synthesis, cytotoxic activity and antitumor activity

(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones:: Synthesis, cytotoxic activity and antitumor activity
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DOI：
10.1016/s0960-894x(00)00447-9
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发表时间：
2000-10-16
期刊：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
影响因子：
2.7
通讯作者：
Ahn, BZ
Ahn, BZ
中科院分区：
医学4区
文献类型：
--
作者：
You, YJ;Kim, Y;Ahn, BZ

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合成的13个(E)-6-(1-alkyloxyiminomethyl)-5，8-dimethoxy-1，4-naphthoquinone衍生物对L1210细胞均表现出较高的ED值，ED50值在0.1~0.3ug/mL之间。然而，它们在A549细胞上不起作用。9个化合物的T/C(%)值(318-388%)高于阿霉素(T/C，315%)。(C)2000爱思唯尔科学有限公司。保留所有权利。
All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED,ED50 values, ranging from 0.1 to 0.3 mug/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%). (C) 2000 Elsevier Science Ltd. All rights reserved.