The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.
The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.
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DOI：
10.1177/10738584221112861
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发表时间：
2022-08
期刊：
影响因子：
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通讯作者：
Arghya Mukherjee;Michael M. Halassa
中科院分区：
文献类型：
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作者：
Arghya Mukherjee;Michael M. Halassa
精神分裂症是一种严重扰乱认知过程的大脑疾病。尽管已经成功地治疗了它的许多症状，但该领域缺乏有效的方法来衡量和解决它对推理、推理和决策的影响。前额叶皮质异常在精神分裂症中已经被很好地记录下来，但最近描述了前额叶皮质和丘脑之间相互作用的额外功能障碍。这种功能障碍可以根据基于非人类动物的神经回路研究的平行进展来解释，这些研究表明，丘脑在维持和转换各种认知任务的前额叶活动模式方面发挥了关键作用。在这里，我们回顾这一基本文献，并将其与临床研究中的新兴创新联系起来。我们强调了关注联想丘脑结构的价值，这不仅是为了更好地理解认知处理的本质，也是为了利用这些回路来诊断和治疗精神分裂症。我们认为，现在是时候在丘脑基础研究和临床翻译之间建立密切的桥梁了，特别是在认知和精神分裂症领域。
Schizophrenia is a brain disorder that profoundly perturbs cognitive processing. Despite the success in treating many of its symptoms, the field lacks effective methods to measure and address its impact on reasoning, inference, and decision making. Prefrontal cortical abnormalities have been well documented in schizophrenia, but additional dysfunction in the interactions between the prefrontal cortex and thalamus have recently been described. This dysfunction may be interpreted in light of parallel advances in neural circuit research based on nonhuman animals, which show critical thalamic roles in maintaining and switching prefrontal activity patterns in various cognitive tasks. Here, we review this basic literature and connect it to emerging innovations in clinical research. We highlight the value of focusing on associative thalamic structures not only to better understand the very nature of cognitive processing but also to leverage these circuits for diagnostic and therapeutic development in schizophrenia. We suggest that the time is right for building close bridges between basic thalamic research and its clinical translation, particularly in the domain of cognition and schizophrenia.