Adjuvants that Enhance Th2 or Tr Responses
Adjuvants that Enhance Th2 or Tr Responses
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DOI：
10.2332/allergolint.54.507
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发表时间：
2005
影响因子：
6.8
通讯作者：
S. Matsushita;Tianyi Liu;M. Wakui;Y. Uemura
中科院分区：
文献类型：
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作者：
S. Matsushita;Tianyi Liu;M. Wakui;Y. Uemura
摘要众所周知，许多Toll样受体（TLR）的同种型作为Th1佐剂受体发挥功能。因此，配体以抗原非特异性方式诱导Th1分化。在过去几年中，不仅报道了Th1佐剂，而且报道了Th2佐剂。致敏物质，如寄生虫，首先刺激树突状细胞（DC）改变其作为专职抗原呈递细胞的特性。这样的DC群体（DC 2）可以刺激幼稚CD 4 T细胞诱导分化为Th 2。在一些情况下，还诱导可刺激调节性T细胞的DC。有趣的是，许多这样的物质是糖脂或磷脂，哺乳动物物种通常不携带。在本文中，我们展示了Th2佐剂的细胞和分子基础。
ABSTRACT It is well-known that many isoforms of toll-like receptors (TLRs) function as Th1 adjuvant receptors. Thus, the ligands induce Th1 differentiation in an antigen non-specific manner. During the past few years, not only Th1, but also Th2 adjuvants have been reported. Allergy-inducing materials, such as parasites, first stimulate dendritic cells (DCs) to change their character as professional antigen-presenting cells. Such a DC population (DC2) can stimulate naive CD4T cells to induce differentiation into Th2. In some instances, DCs that can stimulate regulatory T cells are also induced. Interestingly, many of such substances are glycolipids or phospholipids that mammalian species do not usually carry. In this paper, we show a cellular and molecular basis for Th2 adjuvants.