Glycoconjugates and related molecules in human vascular endothelial cells.
Glycoconjugates and related molecules in human vascular endothelial cells.
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DOI：
10.1155/2013/963596
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发表时间：
2013
影响因子：
1.3
通讯作者：
Toyoda M
中科院分区：
文献类型：
--
作者：
Sasaki N;Toyoda M
血管内皮细胞（EC）形成血管内壁。它们关键参与许多生理功能，包括血管舒缩张力的控制、血细胞运输、止血平衡、通透性、增殖、存活和免疫。人们认为EC功能受损会导致血管疾病的发生。主要存在于细胞表面的糖复合物（例如糖蛋白、糖鞘脂和蛋白聚糖）携带的碳水化合物抗原不仅充当标记分子，而且充当功能分子。最近的研究表明，EC 表面的碳水化合物组成对于这些细胞发挥其生理功能至关重要。在本文中，我们考虑了内源性糖复合物和相关分子（半乳糖凝集素和聚糖降解酶）在人类 EC 中的表达和功能作用。
Vascular endothelial cells (ECs) form the inner lining of blood vessels. They are critically involved in many physiological functions, including control of vasomotor tone, blood cell trafficking, hemostatic balance, permeability, proliferation, survival, and immunity. It is considered that impairment of EC functions leads to the development of vascular diseases. The carbohydrate antigens carried by glycoconjugates (e.g., glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules. Recent studies have revealed that the carbohydrate composition of the EC surface is critical for these cells to perform their physiological functions. In this paper, we consider the expression and functional roles of endogenous glycoconjugates and related molecules (galectins and glycan-degrading enzymes) in human ECs.