Representation of natural stimuli in the rodent main olfactory bulb
Representation of natural stimuli in the rodent main olfactory bulb
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DOI：
10.1016/j.neuron.2006.03.021
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发表时间：
2006-06-15
期刊：
影响因子：
16.2
通讯作者：
Katz, Lawrence C.
中科院分区：
文献类型：
--
作者：
Lin, Da Yu;Shea, Stephen D.;Katz, Lawrence C.
天然香料是多种化合物的复杂混合物。在主嗅球中，单分子气味由激活的肾小球的不同空间模式表示。然而，目前尚不清楚单个化合物如何对自然刺激的群体表示做出贡献，自然刺激似乎出人意料地稀少。我们将气相色谱和内源信号成像相结合，以可视化肾小球对自然刺激及其分离成分的反应。当整个刺激激活最多20个可见肾小球时，每个分离成分只激活一个或少数几个肾小球，大多数肾小球只被一个成分激活。因此，对复杂混合物的反应反映了多个组分的激活，每个组分只占整个表示的一小部分。我们的结论是，群体对复杂刺激的反应很大程度上是对其个别成分的反应的总和，单个肾小球的激活独立地发出特定成分的存在的信号。
Natural odorants are complex mixtures of diverse chemical compounds. Monomolecular odorants are represented in the main olfactory bulb by distinct spatial patterns of activated glomeruli. However, it remains unclear how individual compounds contribute to population representations of natural stimuli, which appear to be unexpectedly sparse. We combined gas chromatography and intrinsic signal imaging to visualize glomerular responses to natural stimuli and their fractionated components. While whole stimuli activated up to 20 visible glomeruli, each fractionated component activated only one or few glomeruli, and most glomeruli were activated by only one component. Thus, responses to complex mixtures reflected activation by multiple components, with each contributing only a small part of the overall representation. We conclude that the population response to a complex stimulus is largely the sum of the responses to its individual components, and activation of an individual glomerulus independently signals the presence of a specific component.