EFFECT OF BETA-CAROTENE SUPPLEMENTATION ON PHOTOSUPPRESSION OF DELAYED-TYPE HYPERSENSITIVITY IN NORMAL YOUNG MEN
EFFECT OF BETA-CAROTENE SUPPLEMENTATION ON PHOTOSUPPRESSION OF DELAYED-TYPE HYPERSENSITIVITY IN NORMAL YOUNG MEN
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DOI：
10.1093/ajcn/56.4.684
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发表时间：
1992-10-01
影响因子：
7.1
通讯作者：
ROE, DA
中科院分区：
文献类型：
--
作者：
FULLER, CJ;FAULKNER, H;ROE, DA
这项研究的目的是检查β-胡萝卜素是否可以防止长波紫外线（UV-A）暴露引起的免疫抑制。 自由生活的健康男性，年龄在19-39岁，接受30毫克β-胡萝卜素/天或安慰剂，同时接受单一菜单，低类胡萝卜素饮食。28 d后，所有受试者在16 d内接受12次UV-A/B光源照射。接受的总UV-A剂量范围为15.9至19.3 J/cm 2。短波紫外线（UV-B）总剂量从1.59到1.96 J/cm 2不等。随访21 d。在基线、UV前、UV后和随访后进行类胡萝卜素测定和迟发型超敏反应（DTH）试验。在紫外线治疗后，安慰剂组的DTH测试反应被显著抑制。在该组中，抑制与血浆β-胡萝卜素浓度呈负相关。在β-胡萝卜素组中，DTH测试反应没有显著抑制。得出结论，β-胡萝卜素可防止免疫功能的光抑制。
The aim of this study was to examine whether beta-carotene protects against the immunosuppression seen with long-wave ultraviolet-light (UV-A) exposure. Free-living, healthy men, aged 19-39 y received 30 mg beta-carotene/d or a placebo while on a single-menu, low-carotenoid diet. After 28 d all subjects received 12 exposures to a UV-A/B light source over a 16-d period. The total UV-A dose received ranged from 15.9 to 19.3 J/cm2. The total shorter-wave ultraviolet-light (UV-B) dose varied from 1.59 to 1.96 J/cm2. Follow-up continued for 21 d. Carotenoid assays and delayed-type hypersensitivity (DTH) tests were performed at baseline, pre-UV, post-UV, and after follow-up. The DTH-test responses were significantly suppressed in the placebo group after UV treatments. The suppression was inversely related to plasma beta-carotene concentrations in this group. There was no significant suppression of DTH test responses in the beta-carotene group. It is concluded that beta-carotene protects against photosuppression of immune function.