EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS .1. EFFECT OF DEXAMETHASONE IN NORMAL EYE
EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS .1. EFFECT OF DEXAMETHASONE IN NORMAL EYE
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DOI：
10.1001/archopht.1963.00960050484010
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发表时间：
1963-01-01
影响因子：
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通讯作者：
ARMALY, MF
中科院分区：
文献类型：
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作者：
ARMALY, MF
本文报告了两个年龄组的正常眼局部应用地塞米松对眼内压和流体动力学的影响。用药4周后，两组均显示眼内压升高，流出道灵活性和房水形成率降低。在老年组中，这种影响的程度明显更大。在所有病例中，在停止药物应用后，在1至2周内完全恢复。对药物影响房水流出能力和房水形成速率的可能机制进行了讨论。本文概述了这种效应的临床意义。报告了两例在临床使用地塞米松治疗期间发生高眼压的病例。
The effect of topical application of dexamethasone in the normal eye on intraocular pressure and fluid dynamics was reported in 2 age groups. Both groups demonstrated an increase in intraocular pressure and a reduction in outflow facility and rate of formation of aqueous after 4 weeks of drug application. The magnitude of the effect was significantly greater in the older age group. Complete recovery, in one to 2 weeks, followed cessation of drug application in all cases. Possible mechanisms of drug action on outflow facility and rate of formation of aqueous were discussed. The clinical significance of this effect was outlined. Two cases that developed ocular hypertension during the therapeutic clinical use of dexamethasone were reported.