THE CD14 MONOCYTE DIFFERENTIATION ANTIGEN MAPS TO A REGION ENCODING GROWTH-FACTORS AND RECEPTORS
THE CD14 MONOCYTE DIFFERENTIATION ANTIGEN MAPS TO A REGION ENCODING GROWTH-FACTORS AND RECEPTORS
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DOI：
10.1126/science.2448876
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发表时间：
1988-01-29
期刊：
影响因子：
56.9
通讯作者：
LEBEAU, MM
中科院分区：
文献类型：
--
作者：
GOYERT, SM;FERRERO, E;LEBEAU, MM
CD14 是一种由单核细胞、巨噬细胞和活化粒细胞表达的骨髓单核细胞分化抗原，可使用单克隆抗体 MO2、MY4 和 LeuM3 进行检测。对 CD14 的互补 DNA 和基因组克隆的分析表明，它具有新颖的结构，并且它映射到包含编码生长因子和受体的其他基因的区域内的 5 号染色体；因此，它可能代表了一种对骨髓分化很重要的新受体。此外，CD14基因位于“关键”区域，该区域在某些髓系白血病中经常被删除。
CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the moncolonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chromosome 5 within a region containing other genes encoding growth factors and receptors; it may therefore represent a new receptor important for myeloid differentiation. In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias.