Fertility preservation in patients with early cervical cancer: Radical trachelectomy
Fertility preservation in patients with early cervical cancer: Radical trachelectomy
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DOI：
10.1016/j.ygyno.2008.03.025
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发表时间：
2008-09-01
影响因子：
4.7
通讯作者：
Frumovitz, Michael
中科院分区：
文献类型：
--
作者：
Ramirez, Pedro T.;Schmeler, Kathleen M.;Frumovitz, Michael
目标。本综述的目的是总结关于根治性气管切除术和早期宫颈癌患者生育结局的最新文献。我们分析了已发表的文献，寻找所有关于宫颈癌根治性气管切除术患者的手术技术、术中和围术期结果以及产科结果的文章。据估计，在美国，所有宫颈癌病例中有43%是在45岁以下的女性中被诊断出来的。截至2007年，共有520名患者接受了阴道根治性气管切除术。大多数患者（60%）被诊断为鳞状细胞癌；腺癌是第二常见的组织学亚型（40%）。关于根治性腹部气管切除术后预后的数据不太广泛，全世界仅报道了大约50例。大约43%接受根治性气管切除术的患者随后试图怀孕。70%的女性成功怀孕。根治性气管切除术安全可行，妊娠结局良好。所有对未来生育能力感兴趣的被诊断为宫颈癌的患者都被鼓励与他们的医生讨论根治性气管切除术。(c) 2008爱思唯尔公司版权所有。
Objectives. The goal of this review is to summarize the latest literature on the subject of radical trachelectomy and fertility outcomes in patients with early-stage cervical cancer.Methods. We analyzed the published literature in search of all articles addressing Surgical techniques, intraoperative and perioperative outcomes, and obstetrical results in patient undergoing radical trachelectomy for cervical cancer.Results. It is estimated that 43% of all cases of cervical cancer in the United States are diagnosed in women younger than 45 years of age. As of 2007, a total of 520 patients had been reported to have undergone a radical vaginal trachelectomy. The majority of patients (60%) had a diagnosis of squamous cell carcinoma; adenocarcinoma was the second most common histologic subtype (40%). Data on outcomes after radical abdominal trachelectomy are less extensive-only approximately 50 cases have been reported worldwide. Approximately 43% of patients who undergo a radical trachelectomy subsequently attempt to become pregnant. Seventy percent of these women are successful at achieving a pregnancy.Conclusions. Radical trachelectomy is safe and feasible and pregnancy outcomes are very favorable. All patients interested in future fertility who are diagnosed with cervical cancer are encouraged to discuss radical trachelectomy with their physician. (c) 2008 Elsevier Inc. All rights reserved.