INVESTIGATION OF THE ABILITY OF SEVERAL NATURALLY-OCCURRING AND SYNTHETIC POLYANIONS TO BIND TO AND POTENTIATE THE BIOLOGICAL-ACTIVITY OF ACIDIC FIBROBLAST GROWTH-FACTOR
INVESTIGATION OF THE ABILITY OF SEVERAL NATURALLY-OCCURRING AND SYNTHETIC POLYANIONS TO BIND TO AND POTENTIATE THE BIOLOGICAL-ACTIVITY OF ACIDIC FIBROBLAST GROWTH-FACTOR
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DOI：
10.1002/jcp.1041570124
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发表时间：
1993-10-01
影响因子：
5.6
通讯作者：
PARISH, CR
中科院分区：
文献类型：
--
作者：
BELFORD, DA;HENDRY, IA;PARISH, CR
The ability of several animal, plant, and bacterial derived polyanions (PAs) as well as synthetic PAs to compete with heparin for the binding of acidic fibroblast growth factor (aFGF) was correlated with their ability to potentiate the mitogenic and neurotrophic actions of this factor. Dextran sulphate, kappa-carrageenan, pentosan sulphate, polyanethole sulfonate, heparin, and fucoidin competed for the heparin binding site on aFGF at relatively low concentrations (
