Long-term adrenomedullin administration in experimental heart failure
Long-term adrenomedullin administration in experimental heart failure
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DOI：
10.1161/01.hyp.0000037132.90640.26
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发表时间：
2002-11-01
期刊：
影响因子：
8.3
通讯作者：
Richards, AM
中科院分区：
文献类型：
--
作者：
Rademaker, MT;Charles, CJ;Richards, AM
肾上腺髓质素是最近发现的一种具有强有力的血管扩张、利钠和醛固酮抑制作用的肽，短期给药对实验性和临床心力衰竭具有有益作用。在这种情况下，长期肾上腺髓质素给药的影响以前没有被评估。因此，在16只患有起搏诱导的心力衰竭的绵羊中，我们输注肾上腺髓质素（每分钟10 ng/kg; n = 8）或载体对照（Hemaccel; n = 8）4天。与对照组数据相比，肾上腺髓质素的输注持续增加了该肽的循环水平（约9.5 pmol/L; P
Short-term administration of adrenomedullin, a recently discovered peptide with potent vasodilator, natriuretic, and aldosterone-inhibitory actions, has beneficial effects in experimental and clinical heart failure. The effects of prolonged adrenomedullin administration have not previously been assessed in this setting. Consequently, in 16 sheep with pacing-induced heart failure, we infused either adrenomedullin (10 ng/kg per minute; n=8) or a vehicle control (Hemaccel; n=8) for 4 days. Compared with control data, infusion of adrenomedullin persistently increased circulating levels of the peptide (by approximate to9.5 pmol/L; P