Esophageal involvement in Behcet's disease
Esophageal involvement in Behcet's disease
复制标题
DOI：
10.3349/ymj.2002.43.4.457
复制
发表时间：
2002-08-01
影响因子：
2.4
通讯作者：
Miled, M
中科院分区：
文献类型：
--
作者：
Houman, MH;Ben Ghorbel, I;Miled, M
白塞氏病累及食管的情况非常罕见，通常表现为食管坏死和食管炎，但也可能出现糜烂、穿孔、狭窄等严重并发症。我们进行这项前瞻性研究是为了评估白塞氏病食管受累的患病率，并确定是否有必要进行常规内窥镜检查和/或测压。符合白塞氏病国际研究组诊断标准的 23 名患者入组。没有人服用药物或患有可能导致食管异常或改变白塞氏病本身引起的任何现有变化的疾病。 23 名患者由一名观察者接受了食管胃十二指肠镜检查。对 13 名患者进行了食管活检，对 20 名患者进行了食管测压。在研究开始时，疾病活动性的定义是存在一种以上与白塞病相关的症状，并根据白塞病的分类进行定义。在纳入的 23 名患者中，有 2 名患者因存在食管裂孔疝而被排除在最终分析之外。因此，纳入了 13 名男性和 8 名女性，年龄从 20 岁到 63 岁，平均年龄 36.2 岁。十名患者（47.6%）患有活动性疾病，四名患者（19%）在研究时抱怨有上消化道症状。十四名患者有内窥镜检查、测压和/或显微镜检查异常。 20 例患者进行了食管测压，7 例（35%）异常。13 例患者进行了食管活检，5 例发现组织病理学异常。镜下可见血管病变1例，以中性粒细胞为主的非特异性炎症浸润4例。我们的结果表明，白塞氏病食管受累的患病率相当高，甚至在无症状患者中也会发生，但这通常不会导致特定的异常。
Esophageal involvement in Behcet's disease is very rare, and normally is observed as aphtosis and esophagitis, but serious complications such as erosions, perforations, and stenosis may occur. We carried out this prospective study to evaluate the prevalence of esophageal involvement in Behcet's disease and to establish if routine endoscopy and/or manometry are necessary. Twenty-three patients who fulfilled the diagnostic criteria of the international study group for Behcet's disease were enrolled. None were taking drugs or had disease that might produce esophageal abnormalities or alter any existing changes due to the Behcet's disease itself. Twenty-three patients underwent esophagogastroduodenoscopy by a single observer. Esophageal biopsies were performed in thirteen patients and esophageal manometry in twenty. At the beginning of the study, the disease activity was defined by the presence of more than one symptom related to Behcet's disease, and upon the classification of Behcet's disease. Of the twenty three patients enrolled two were excluded from final analysis because of the presence of hiatus hernia. Thus, 13 men and 8 women, ranging in age from 20 to 63 years with a mean age of 36.2 years were included. Ten patients (47.6%) had active disease and four (19%) complained of upper gastrointestinal symptoms at the time of the study. Fourteen patients had endoscopic, manometric and/or Microscopic abnormalities. Esophageal manometry was performed in twenty patients and was abnormal in 7 cases (35%), Esophageal biopsies were done in 13 patients and revealed histopathological abnormalities in 5 cases. Microscopic findings showed vasculities in one case, and non-specific inflammatory infiltration mainly consisting of neutrophils in 4 cases. Our results suggest that the prevalence of esophageal involvement in Behcet's disease is rather high and occur even in asymptomatic patients, but that this usually does not result in specific abnormalities.