Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine
Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine
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DOI：
10.1126/science.277.5328.953
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发表时间：
1997-08-15
期刊：
影响因子：
56.9
通讯作者：
Roth, RH
中科院分区：
文献类型：
--
作者：
Jentsch, JD;Redmond, DE;Roth, RH
研究了拟精神病药物苯环己哌啶对黑长尾猴神经化学和前额皮质功能的影响，每天两次接受苯环己哌啶治疗，持续 14 天，猴子在对前额皮质功能敏感的任务中表现出表现缺陷；非典型抗精神病药物氯氮平改善了这些缺陷，反复接触苯环己哌啶导致背外侧前额皮质（长期以来与认知功能相关的大脑区域）的基础多巴胺利用和诱发多巴胺利用减少，停止苯环己哌啶治疗后仍然存在行为缺陷和多巴胺利用减少，这表明这些影响是 不仅仅是由于药物的直接作用。数据表明，在猴子身上重复施用苯环己哌啶可能有助于研究与认知功能障碍和前额皮质多巴胺功能减退相关的精神疾病，特别是精神分裂症。
The effects of the psychotomimetic drug phencyclidine on the neurochemistry and function of the prefrontal cortex in vervet monkeys were investigated, Monkeys treated with phencyclidine twice a day for 14 days displayed performance deficits on a task that was sensitive to prefrontal cortex function; the deficits were ameliorated by the atypical antipsychotic drug clozapine, Repeated exposure to phencyclidine caused a reduction in both basal and evoked dopamine utilization in the dorsolateral prefrontal cortex, a brain region that has long been associated with cognitive function, Behavioral deficits and decreased dopamine utilization remained after phencyclidine treatment was stopped, an indication that these effects were not simply due to direct drug effects. The data suggest that repeated administration of phencyclidine in monkeys may be useful for studying psychiatric disorders associated with cognitive dysfunction and dopamine hypofunction in the prefrontal cortex, particularly schizophrenia.