Is volumetric 3-dimensional computed tomography useful to predict histological tumour invasiveness? Analysis of 211 lesions of cT1N0M0 lung adenocarcinoma
Is volumetric 3-dimensional computed tomography useful to predict histological tumour invasiveness? Analysis of 211 lesions of cT1N0M0 lung adenocarcinoma
复制标题
DOI：
10.1093/icvts/ivw037
复制
发表时间：
2016-06-01
影响因子：
--
通讯作者：
Date, Hiroshi
中科院分区：
文献类型：
--
作者：
Shikuma, Kei;Menju, Toshi;Date, Hiroshi
目标：本研究的目的是使用Hounsfield单位（HU）阈值的计算机断层扫描（CT）图像预测病理淋巴结转移和肿瘤侵袭cT 1 N 0 M0肺腺癌的三维evaluations.Methods：术前CT图像211例病灶手术切除cT 1 N 0 M0肺腺癌进行了回顾性检查。在1D、2D和3D视图中计算肿瘤大小。-300 HU及以上的肿瘤定义为“实体瘤”，-800和-301 HU之间的肿瘤定义为“毛玻璃样阴影肿瘤”。假设~ 800 HU及以上的肿瘤为整个肿瘤实体。整个肿瘤实体中的“实体瘤”比例也计算为“实体瘤比率”。结果：实体瘤的大小和比例与胸膜、血管和毛细血管的浸润呈正相关。在所有维度的评估中，实体瘤的大小和比率也可以很好地预测病理性淋巴结转移。1D、1D x2、2D和3D评价的受试者工作特征（ROC）曲线的P值分别为：实体瘤大小P = 0.013、0.014和0.032;实体瘤比率为0.016、0.0032和0.0033。
OBJECTIVES: The purpose of this study was to use Hounsfield unit (HU) thresholds of computed tomography (CT) images to predict pathological lymph node metastasis and tumour invasiveness of cT1N0M0 lung adenocarcinoma on 3D evaluations.METHODS: Preoperative CT images of 211 lesions of surgically resected cT1N0M0 lung adenocarcinoma were retrospectively examined. The tumour size was calculated in 1D, 2D and 3D views. Tumours with -300 HU and over were defined as 'solid tumours', and those between -800 and -301 HU were defined as 'ground glass opacity tumours'. Tumours with -800 HU and over were assumed to be the whole tumour entity. The proportion of 'solid tumour' within the whole tumour entity was also calculated as the 'solid tumour ratio'. These were compared with pathological information.RESULTS: Solid tumour size and ratio were positively correlated with microscopic invasion to pleura, vessels and lymphatics in all dimensional evaluations. Pathological lymph node metastases were also well predicted by solid tumour size and ratio in all dimensional evaluations. The P-values for the receiver operating characteristic (ROC) curves of 1D, 1D x2, 2D and 3D evaluations were: solid tumour size P = 0.013, 0.014 and 0.032; and solid tumour ratio 0.016, 0.0032 and