Pregnancy-induced hypertension is associated with an increase in the prevalence of cardiovascular disease risk factors in Japanese women
Pregnancy-induced hypertension is associated with an increase in the prevalence of cardiovascular disease risk factors in Japanese women
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DOI：
10.1097/gme.0000000000000361
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发表时间：
2015-06-01
影响因子：
2.7
通讯作者：
Miyano, Ichiro
中科院分区：
文献类型：
--
作者：
Watanabe, Kazushi;Kimura, Chiharu;Miyano, Ichiro
目的：评估妊娠高血压综合征(PIH)是否影响日本女性晚年心血管疾病(CVD)危险因素的患病率。方法：研究对象为1185名40岁或以上的日本女性，平均年龄46.5[5.6]岁，38-73岁，2012年1月至2013年12月在定期体检机构接受体检，并有过生育经历。向潜在参与者发送了调查问卷，鼓励他们提供《妇幼保健手册》(手册)。我们招募了101名有妊高征史的妇女(妊高征组)和1084名分娩时无并发症妊娠的妇女(对照组)。分组是根据手册中的信息进行的。我们通过重点研究高血压、糖尿病和血脂异常作为心血管疾病的危险因素，评估了日本女性晚年妊娠高血压综合征与心血管疾病之间的关系。结果：与非妊高征组相比，妊高征组使用抗高血压药物的风险增加(2.9%比13.9%；OR=4.28；95%CI=2.14~8.57)。妊高征组的甘油三酯显著高于对照组，高密度脂蛋白胆固醇显著低于对照组。与对照组相比，妊高征组使用降血脂药物的OR值为3.20(95%CI，1.42~7.22)。结论：我们的研究结果提示，妊高征史可能与日本女性晚年患高血压(心血管疾病的危险因素)的风险增加有关。
Objective: This study assessed whether pregnancy-induced hypertension (PIH) affects the prevalence of cardiovascular disease (CVD) risk factors in later life among Japanese women.Methods: Study participants were 1,185 women (mean [SD] age, 46.5 [5.6] y; range, 38-73 y) aged 40 years or older who underwent a health checkup at a periodic health examination facility between January 2012 and December 2013 and had experienced giving birth. Questionnaires were sent to potential participants, and they were encouraged to provide their Maternal and Child Health Handbook (handbook). We recruited 101 women with a history of PIH (PIH group) and 1,084 women with uncomplicated pregnancy at delivery (control group). Groupings were based on information from the handbook. We assessed the association between PIH and CVD in later life among Japanese women by focusing on hypertension, diabetes mellitus, and dyslipidemia as risk factors for CVD. Odds ratios (ORs) for the use of antihypertensive, diabetes mellitus, and dyslipidemic medications in the PIH group were determined.Results: Women with PIH had increased risk of antihypertensive medication use compared with women without PIH (2.9% vs 13.9%; OR, 4.28; 95% CI, 2.14-8.57). Triglycerides were significantly higher and high-density lipoprotein cholesterol was significantly lower in the PIH group than in the control group. The OR for dyslipidemic medication use in the PIH group relative to the control group was 3.20 (95% CI, 1.42-7.22).Conclusions: Our findings suggest that a history of PIH may be associated with an increased risk of hypertension (a risk factor for CVD) in later life among Japanese women.