Facilitated acquisition of the classically conditioned eyeblink response in women taking oral contraceptives
Facilitated acquisition of the classically conditioned eyeblink response in women taking oral contraceptives
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DOI：
10.1097/fbp.0b013e32831c3b82
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发表时间：
2008-12-01
影响因子：
1.6
通讯作者：
Servatius, Richard J.
中科院分区：
文献类型：
--
作者：
Beck, Kevin D.;McLaughlin, Joselyn;Servatius, Richard J.
尽管坊间报道表明联想学习过程受月经阶段的影响，但经验证据一直不明确。此外，关于人工或外源性女性荷尔蒙对学习和记忆的影响的研究也很少。因此，在这项初步研究中，我们评估了在月经周期的三个阶段：早期、中期和晚期服用口服避孕药的妇女和没有服用避孕药的妇女的学习情况。行为学评估包括短时间眨眼条件反射、听觉惊吓反应和精细运动协调任务(带槽的钉板)。口服避孕药使用者通常比非使用者获得更好的条件眨眼反应。在精细运动协调和惊吓反应方面也观察到了类似的增强。进一步的研究将需要区分荷尔蒙的影响是在联想过程中还是在非联想学习中涉及的感觉-运动通路上。行为药理学19：821-828(C)2008 Wolters Kluwer Health|Lippincott Williams&Wilkins。
Although anecdotal reports suggest that associative learning processes are affected by menstrual phase, empirical evidence has been equivocal. Moreover, there is a dearth of research concerning fluctuations of artificial or exogenous female hormones on learning and memory. Therefore, in this preliminary study we assessed learning in women who take oral contraceptives and those who do not during the three phases of the menstrual cycle: early, middle, and later cycle. The behavioral assessment included short-trace eyeblink conditioning, acoustic startle reactivity, and a fine motor coordination task (grooved pegboard). Oral contraceptive users generally acquired the conditioned eyeblink response better than non-users. Similar enhancements were observed for fine motor coordination and startle responsiveness. Further research will need to distinguish whether the hormone influence is upon the associative processes or the sensory-motor pathways involved in nonassociative learning. Behavioural Pharmacology 19:821-828 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.