Diffusion tensor imaging of native and degenerated human articular cartilage
Diffusion tensor imaging of native and degenerated human articular cartilage
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DOI：
10.1016/j.mri.2006.10.015
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发表时间：
2007-02-01
影响因子：
2.5
通讯作者：
Burstein, Deborah
中科院分区：
文献类型：
--
作者：
Deng, Xiang;Farley, Michelle;Burstein, Deborah
弥散张量成像(DTI)对软骨中的胶原变性具有潜在的敏感性。在这项研究中，在胰酶和胶原酶的干预下，测量了人软骨样本的DTI。测得的择优扩散方向与胶原网的带状结构一致。两种干预措施均可降低糖胺多糖浓度，增加表观扩散系数。部分各向异性(FA)不受胰酶影响，联合应用胰酶和胶原酶干预后，FA略有增加。软骨中的DTI在技术上是具有挑战性的，因为低FA和几乎无法检测到的胶原蛋白破坏的变化。(C)2007 Elsevier Inc.保留所有权利。
Diffusion tensor imaging (DTI) is potentially sensitive to collagen degeneration in cartilage. In this study, DTI was measured on human cartilage samples with interventions of trypsin and collagenase. The measured preferred diffusion direction was consistent with the zonal structure of collagen network. The glycosaminoglycan concentration decreased and apparent diffusion coefficient increased with both interventions. The fractional anisotropy (FA) was not affected by trypsin and showed a slight increase with combined trypsin and collagenase intervention. DTI in cartilage is technically challenging due to the low FA and the almost undetectable change with collagen disruption seen here. (c) 2007 Elsevier Inc. All rights reserved.