A decreased survival of proliferated cells in the hippocampus is associated with a decline in spatial memory in aged rats
A decreased survival of proliferated cells in the hippocampus is associated with a decline in spatial memory in aged rats
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DOI：
10.1016/j.neulet.2006.01.056
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发表时间：
2006-05
影响因子：
2.5
通讯作者：
Henny Wati;K. Kudo;Chunxiang Qiao;T. Kuroki;S. Kanba
中科院分区：
文献类型：
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作者：
Henny Wati;K. Kudo;Chunxiang Qiao;T. Kuroki;S. Kanba
在老年大鼠中，虽然学习和记忆障碍是突出的，但已知海马中颗粒细胞的数量和神经元祖细胞增殖的程度都被保留下来。我们研究了海马新生神经元的存活与老年大鼠学习能力之间的关系。通过使用细胞增殖标记物BrdU来确定神经发生和背景恐惧条件反射来确定学习能力，我们发现在老年大鼠中，沿着记忆障碍，基线时增殖细胞和那些通过背景恐惧条件反射增强的细胞的存活率显著降低。这些结果提示，随着年龄的增长，新生神经元在海马回路中的整合减少，这一现象可能是老年大鼠学习记忆能力下降的部分原因。
In aged rats, although learning and memory impairment is prominent, both the number of granular cells and the degree of neuronal progenitor proliferation in the hippocampus are known to be preserved. We examined the association between the survival of newly generated neurons in the hippocampus and the learning ability in aged rats. By using BrdU, a cell proliferation marker to determine neurogenesis and contextual fear conditioning to determine learning ability, we found that in aged rats, along with memory impairment, the survival of both the proliferated cells at baseline and those enhanced by contextual fear conditioning decreased remarkably. These results suggest that the integration of newly generated neurons into hippocampal circuitry is decreased with aging, this phenomenon may, in part, explain the decline in learning and memory in aged rats.