Altered brain tissue composition in heavy marijuana users
Altered brain tissue composition in heavy marijuana users
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DOI：
10.1016/j.drugalcdep.2004.06.011
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发表时间：
2005-01-07
影响因子：
4.2
通讯作者：
Bolla, KI
中科院分区：
文献类型：
--
作者：
Matochik, JA;Eldreth, DA;Bolla, KI
然而，大麻是美国使用最广泛的非法物质。之前的影像学研究并未发现吸食大麻的人与不吸食大麻的人相比大脑结构发生了变化。基于体素的形态测定法被用来研究 11 名重度大麻使用者和 8 名不吸食大麻者的脑组织成分可能存在的差异。所有参与者均为男性。在 T1 加权磁共振图像的体素水平上进行统计比较，以确定灰质和白质组织密度的差异。与非使用者相比，吸食大麻的人右侧海马旁回体素簇的灰质密度较低（P = 0.0001）。中央前回和右侧丘脑附近的双侧密度更大（P < 0.0-4）。与不吸食大麻的人相比，吸食大麻的人左顶叶白质密度较低（P = 0.03），而左侧海马旁回和梭状回周围的白质密度较高（P < 0.002）。较长的吸食大麻时间（以年为单位）与左侧中央前回较高的白质组织密度显着相关（P = 0.045）。我们的初步结果表明，吸食大麻的人的大脑可能存在结构差异。并定位区域以进一步研究大麻对大脑的影响。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Marijuana is the most widely used illicit substance in the United States: however. previous imaging studies have not detected altered brain structure in marijuana users compared to non-users. Voxel-based morphometry was used to investigate possible differences in brain tissue composition in a group of 11 heavy marijuana users and a group of 8 non-users. All participants were male. Statistical comparisons were made at the voxel level on T1-weighted magnetic resonance images to determine differences in gray matter and white matter tissue density Compared to non-users, marijuana users had lower gray matter density in a cluster of voxels in the right parahippocampal gyrus (P = 0.0001). and greater density bilaterally near the precentral gyrus and the right thalamus (P < 0.0-4). Marijuana users also had lower white matter density, in the left parietal lobe (P = 0.03), and higher density around the parahippocampal and fusiform gyri on the left side compared to non-users (P < 0.002). Longer duration of marijuana use (in years) was significantly correlated with higher white matter tissue density in the left precentral gyrus (P = 0.045). Our preliminary results suggest evidence of possible structural differences in the brain of heaxy marijuana users. and localize regions for further investigation of the effects of marijuana in the brain. (C) 2004 Elsevier Ireland Ltd. All rights reserved.