SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats
SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats
复制标题
DOI：
10.1016/s0014-2999(00)00615-4
复制
发表时间：
2000-09-15
影响因子：
5
通讯作者：
Lichtman, AH
中科院分区：
文献类型：
--
作者：
Lichtman, AH
已经提出了具有紧张活性的内源性大麻素系统来调节学习和记忆。本研究的目的是确定大麻素CB 1受体拮抗剂N-（哌啶-1-基）-5-（4-氯苯基）-1-（2，3-二氯苯基）-4-甲基-1H-吡唑-3-甲酰胺盐酸盐（SR 141716 A）给药是否会增强八臂径向迷宫任务中评估的记忆。由于在标准的径向臂迷宫程序的选择精度高排除了检测记忆增强的可能性，任务的难度增加了由采集和测试阶段组成的两阶段程序之间施加不同持续时间的延迟。注射SR 141716 A后，测试阶段发生的错误明显少于溶剂处理。这些结果提供了额外的证据支持内源性大麻素系统在记忆过程中发挥作用的假设。(C)2000 Elsevier Science B. V.保留所有权利。
A tonically active endogenous cannabinoid system has been proposed to modulate learning and memory. The purpose of the present study was to determine whether administration of the cannabinoid CB1 receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,3-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR 141716A) would enhance memory as assessed in an eight-arm radial maze task. Because the high degree of choice accuracy in the standard radial-arm maze procedure precludes the possibility of detecting memory enhancement, the difficulty of the task was increased by imposing a delay of varying durations between a two-phase procedure consisting of acquisition and test phases. Significantly fewer errors were committed during the test phase following an injection of SR 141716A than the vehicle treatment. These results provide additional evidence supporting the hypothesis that endogenous cannabinoid systems play a role in memory processes. (C) 2000 Elsevier Science B.V. All rights reserved.