Spectroscopic imaging of nano-particle distribution in biological tissue using optically assisted ultrasonic velocity-change detection
Spectroscopic imaging of nano-particle distribution in biological tissue using optically assisted ultrasonic velocity-change detection
复制标题
使用光学辅助超声速度变化检测对生物组织中纳米颗粒分布进行光谱成像
DOI：
10.1109/ultsym.2008.0315
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
H. Horinaka
中科院分区：
文献类型：
--
作者：
S. Kawakami;N. Nakamura;T. Mukaiyama;S. Ishibasi;K. Wada;T. Matsuyama;T. Matsunaka;K. Kono;H. Horinaka
采用光学辅助超声变速成像方法，在组织模拟体模中获得了有望作为药物释放系统和光热治疗标记物的纳米颗粒的光谱图像。制备了包括金纳米棒或半导体纳米颗粒的纳米颗粒。采用与纳米颗粒吸收光谱相对应的不同发射波长的半导体激光器照射，获得了体模的超声速度变化图像。实验结果表明，我们的方法有可能找到生物组织中的光吸收剂。
The optically assisted ultrasonic velocity-change imaging method was applied to obtain the spectroscopic image of nano-particles, which were expected as markers for drug delivery system and photo-thermal therapy, in tissue mimic phantoms. Phantoms including gold nano-rods or semiconductor nano-particles were prepared. The ultrasonic velocity-change images of phantoms were obtained using illumination of laser diodes with various emission wavelengths corresponded to the absorption spectrum of nano-particle. Experimental results showed that our method has the potential to find the optical absorption agent in biological tissue.