Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin
Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin
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DOI：
10.1016/j.neuroimage.2005.05.052
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发表时间：
2005-10-01
期刊：
影响因子：
5.7
通讯作者：
Boas, DA
中科院分区：
文献类型：
--
作者：
Culver, JP;Siegel, AM;Boas, DA
为了评估血流动力学对比的相对性能，映射大脑活动，氧，脱氧和总血红蛋白浓度的时空响应进行成像与扩散光学断层扫描在大鼠体感皮层的电刺激。对于6秒和30秒的刺激持续时间，总血红蛋白图像提供了更小的激活面积比氧合或脱氧血红蛋白图像。此外，对矢状窦静脉附近感兴趣区域的分析显示，相对于总血红蛋白，氧合和脱氧的对比度显著更大，这表明在给定的刺激条件下，与总血红蛋白对比度相比，血氧对比度具有更大的引流静脉贡献。这些结果表明，总血红蛋白和脑血容量作为血流动力学标测对比可能具有优势，特别是对于大振幅、持续时间较长的刺激范例。(C)2005年爱思唯尔公司All rights reserved.
With the aim of evaluating the relative performance of hemodynamic contrasts for mapping brain activity, the spatio-temporal response of oxy-, deoxy-, and total-hemoglobin concentrations were imaged with diffuse optical tomography during electrical stimulation of the rat somatosensory cortex. For both 6-s and 30-s stimulus durations, total hemoglobin images provided smaller activation areas than oxy- or deoxy-hemoglobin images. In addition, analysis of regions of interest near the sagittal sinus vein show significantly greater contrast in both oxy- and deoxy-relative to total hemoglobin, suggesting that oximetric contrasts have larger draining vein contributions compared to total hemoglobin contrasts under the given stimulus conditions. These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms. (C) 2005 Elsevier Inc. All rights reserved.