Effect of a Biofeedback Intervention on Heart Rate Variability in Individuals With Panic Disorder: A Randomized Controlled Trial
Effect of a Biofeedback Intervention on Heart Rate Variability in Individuals With Panic Disorder: A Randomized Controlled Trial
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DOI：
10.1097/psy.0000000000001031
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发表时间：
2022-02-01
影响因子：
3.3
通讯作者：
Petrowski, Katja
中科院分区：
文献类型：
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作者：
Herhaus, Benedict;Siepmann, Martin;Petrowski, Katja
目的惊恐障碍（PD）患者心率变异性（HRV）降低，可能导致心血管死亡风险增加。心率变异性生物反馈（HRV-BF）训练已被证明可以改善自主活动的调节。因此，本随机对照试验旨在研究4周HRV-BF干预对PD患者的影响。HRV BF训练改善了自主活动的调节。因此，通过这项随机对照试验，我们的目的是研究为期4周的HRV BF干预对PD患者的影响。方法36例女性PD患者和16例男性PD患者（平均年龄35.85 [15.60]岁），随机分为0.1 Hz呼吸的HRV BF干预组和HRV Sham BF对照组。HRV BF进行了4周，而HRV在短期休息条件下，并在干预前后的起搏呼吸条件下进行测量。结果0.1 Hz呼吸的HRV BF增加了PD患者的HRV，减少了惊恐症状。0.1Hz呼吸的心率变异性BF在短期静息状态下表现出心率变异性的时域和频域参数增加（Delta Post-Pre均方根连续差：5.87 [14.03]毫秒;所有NN间期的Delta Post-Pre标准差：11.63 [17.06]毫秒; Delta Post-Pre总功率：464.88 [1825.47]毫秒（2）; 0.04-0.15 Hz低频范围内的Delta Post-Pre功率：312.73 [592.71]毫秒（2）），起搏呼吸条件下心率降低（治疗前-治疗后Δ：-5.87 [9.14]次/分），恐慌和广场恐怖量表降低（治疗前-治疗后Δ：-3.64 [6.30]）。HRV-Sham-BF组无干预作用。结论HRV-BF作为一种非侵入性和非药物治疗，似乎是一个重要的干预选择，以改善降低的HRV和减少惊恐症状的个人与PD。未来的研究需要确定这些作用是否转化为PD患者心血管疾病风险的降低。
Objective Some individuals with panic disorder (PD) display reduced heart rate variability (HRV), which may result in an increased risk of cardiovascular mortality. Heart rate variability-biofeedback (HRV-BF) training has been shown to improve the modulation of the autonomic activity. Therefore, this randomized controlled trial was conducted to investigate the effect of a 4-week HRV-BF intervention in individuals with PD. HRV-BF training improved the modulation of the autonomic activity. Therefore, with this randomized controlled trial, we aimed to investigate the effect of a 4-week HRV-BF intervention in people with PD. Methods Thirty-six women and 16 men with PD (mean age = 35.85 [15.60] years) were randomly allocated either to HRV-BF with 0.1-Hz breathing as intervention group or to HRV-Sham-BF as active control group. HRV-BF was performed for 4 weeks, whereas HRV was measured both during a short-term resting condition and during a paced breathing condition before and after intervention. Results HRV-BF with 0.1-Hz breathing increased HRV and reduced panic symptoms in individuals with PD. HRV-BF with 0.1-Hz breathing demonstrated an increase in the time and frequency domain parameters of HRV during the short-term resting condition (Delta Post-Pre root mean square successive differences: 5.87 [14.03] milliseconds; Delta Post-Pre standard deviation of all NN intervals: 11.63 [17.06] milliseconds; Delta Post-Pre total power: 464.88 [1825.47] milliseconds(2); Delta Post-Pre power in low-frequency range 0.04-0.15 Hz: 312.73 [592.71] milliseconds(2)), a decrease in the heart rate during the paced breathing condition (Delta Post-Pre: -5.87 [9.14] beats/min), and a decrease in the Panic and Agoraphobia Scale (Delta Post-Pre: -3.64 [6.30]). There was no intervention effect in the HRV-Sham-BF group. Conclusions HRV-BF as a noninvasive and nonpharmacological treatment seems to be an important intervention option to improve reduced HRV and decrease panic symptoms in individuals with PD. Future studies are needed to establish whether these effects translate to reductions in the risk of cardiovascular disease in PD.