The class I-restricted cytotoxic T lymphocyte response to predetermined epitopes in the hepatitis B and C viruses.
The class I-restricted cytotoxic T lymphocyte response to predetermined epitopes in the hepatitis B and C viruses.
复制标题
I 类限制性细胞毒性 T 淋巴细胞对乙型和丙型肝炎病毒中预定表位的反应。
DOI：
10.1007/978-3-642-78530-6_10
复制
发表时间：
1994
影响因子：
--
通讯作者：
Chisari,FV
中科院分区：
文献类型：
--
作者：
Cerny,A;Ferrari,C;Chisari,FV
丙型肝炎病毒（HBV和HCV）最初均被确定为输血相关肝炎的病原体，具有诱发急性和慢性肝炎以及肝细胞癌的倾向（TIOLLAIS et al. 1981; CHao et al. 1989）。尽管有这些生物学上的相似之处，这两种病毒却有很大的不同。HBV具有约3200个核苷酸的部分双链DNA基因组，感染性颗粒大小为42 nm且有包膜，病毒属于嗜肝DNA病毒科; HCV具有约10000个核苷酸的正链RNA基因组，大小小于80 nm，由于其对有机溶剂的敏感性而可能被包膜，并且它与披膜病毒科或黄病毒科有关（霍顿等，1991）。HBV和HCV引起急性肝细胞损伤并引发导致慢性肝病并最终导致肝细胞癌的一系列事件的机制还不清楚。直接的、病毒相关的或间接的（即免疫介导的）机制都可能发挥重要作用。直接细胞病变分析
Hepatitis Band C viruses (HBV and HCV) both originally identified as causative agents of transfusion-associated hepatitis share a propensity to induce acute and chronic hepatitis and hepatocellular carcinoma (TIOLLAIS et al. 1981; CHao et al. 1989). Despite these biologica1 similarities, the two viruses differ considerably. HBV has a partially double-stranded DNA genome of about 3200 nucleotides, infectious particles are 42 nm in size and are enveloped, and the virus belongs to the hepadnavirus family; HCV has a positive-stranded RNA genome of approximately 10000 nucleotides, is less than 80 nm in size, is probably enveloped due to its sensitivity to organic solvents, and it is related to the Togaviridae or Flaviviridae (HOUGHTON et al. 1991).The mechanisms whereby HBV and HCV cause acute hepatocellular injury and initiate the sequence of events leading to chronic liver disease and ultimately to hepatocellular carcinoma are not well understood. It is possible that both direct, virus-related or indirect, ie, immunologically mediated, mechanisms may play an important role. Analysis of the direct cytopathic