Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort.
Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort.
复制标题
DOI：
10.1158/1055-9965.epi-17-0744
复制
发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Kaaks R
中科院分区：
文献类型：
--
作者：
Cramer DW;Fichorova RN;Terry KL;Yamamoto H;Vitonis AF;Ardanaz E;Aune D;Boeing H;Brändstedt J;Boutron-Ruault MC;Chirlaque MD;Dorronsoro M;Dossus L;Duell EJ;Gram IT;Gunter M;Hansen L;Idahl A;Johnson T;Khaw KT;Krogh V;Kvaskoff M;Mattiello A;Matullo G;Merritt MA;Nodin B;Orfanos P;Onland-Moret NC;Palli D;Peppa E;Quirós JR;Sánchez-Perez MJ;Severi G;Tjønneland A;Travis RC;Trichopoulou A;Tumino R;Weiderpass E;Fortner RT;Kaaks R
肿瘤和非肿瘤事件可能会提高粘蛋白，CA15.3和CA 125的水平，并产生针对它们的抗体;但它们对上皮性卵巢癌（EOC）风险的影响尚未完全确定。在欧洲营养与癌症前瞻性调查中，对806名患EOC的妇女和1,927名匹配的对照者进行了CA15.3、CA 125和IgG 1抗体检测。使用广义线性模型评价流行病学因素与抗粘蛋白抗体之间的相关性;使用条件Logistic回归评价抗粘蛋白抗体本身或与各自抗原组合相关的EOC风险。在对照组中，抗两种粘蛋白的抗体较低与当前吸烟有关;在绝经后妇女中，较长时间口服避孕药使用和较晚年龄-在和较短的间隔-自上次生育以来，抗体水平较高。较低的抗CA 15.3抗体与较高的体重相关，在绝经前妇女中，排卵周期更多。较高的抗CA15.3和抗CA 125抗体与入组后≥ 3年发生粘液性EOC的风险较高相关。血清性卵巢癌的长期风险在低CA 125和高抗CA 125抗体的女性中相对于两者浓度都低的女性降低。我们发现抗粘蛋白抗体水平与EOC危险因素相关的假设得到了普遍支持。抗体单独或与其抗原组合可预测特定EOC类型的长期风险。抗CA 125和抗CA 15.3抗体单独或结合抗原可能有助于了解EOC亚型的发病机制，但对所有EOC的风险评估作用不大。
Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3 and CA125, and generate antibodies against them; but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression. In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both. We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types. Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC.