RNA granules: the good, the bad and the ugly.
RNA granules: the good, the bad and the ugly.
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DOI：
10.1016/j.cellsig.2010.08.011
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发表时间：
2011-02
影响因子：
4.8
通讯作者：
Boccaccio GL
中科院分区：
文献类型：
--
作者：
Thomas MG;Loschi M;Desbats MA;Boccaccio GL
处理体(PBS)和应激颗粒(SGS)是一类新的RNA颗粒的创始成员，被称为mRNA沉默焦点，因为它们含有间接排除在翻译活性池之外的转录本。PBS和SGS能够释放mRNAs，从而允许它们的翻译。PBS是结构性的，但对影响mRNA翻译和衰退的刺激做出反应，而SGS是在细胞应激时特异性诱导的，这通过几种途径触发全球翻译沉默，包括关键翻译起始因子eIF2pha的磷酸化和tRNA切割等。不同组成的PBS和SGS可以共存于单个细胞中。这些大分子聚集体在进化过程中高度保守，从单细胞生物体到脊椎动物神经元。它们的动力学受几条信号通路的调节，依赖于微丝和微管，以及同源分子马达肌球蛋白、动力蛋白和动蛋白。SGS与神经退行性疾病中常见的侵袭体和相关的未折叠蛋白聚集体具有相同的特征，并可能在病理中发挥作用。病毒感染可诱导或损害SG的形成。SGS除了对应激状态下的mRNA调控具有重要作用外，还参与调节细胞凋亡和细胞存活的信号转导。最后，与SGS成分相同的核应激体(NSB)的形成，以及含有RNA的额外细胞质聚集体的组装--UV颗粒和IRE1焦点--都是由特定的细胞损伤因子诱导的，有助于细胞存活。
Processing bodies (PBs) and Stress Granules (SGs) are the founding members of a new class of RNA granules, known as mRNA silencing foci, as they harbour transcripts circumstantially excluded from the translationally active pool. PBs and SGs are able to release mRNAs thus allowing their translation. PBs are constitutive, but respond to stimuli that affect mRNA translation and decay, whereas SGs are specifically induced upon cellular stress, which triggers a global translational silencing by several pathways, including phosphorylation of the key translation initiation factor eIF2alpha, and tRNA cleavage among others. PBs and SGs with different compositions may coexist in a single cell. These macromolecular aggregates are highly conserved through evolution, from unicellular organisms to vertebrate neurons. Their dynamics is regulated by several signaling pathways, and depends on microfilaments and microtubules, and the cognate molecular motors myosin, dynein, and kinesin. SGs share features with aggresomes and related aggregates of unfolded proteins frequently present in neurodegenerative diseases, and may play a role in the pathology. Virus infections may induce or impair SG formation. Besides being important for mRNA regulation upon stress, SGs modulate the signaling balancing apoptosis and cell survival. Finally, the formation of Nuclear Stress Bodies (nSBs), which share components with SGs, and the assembly of additional cytosolic aggregates containing RNA –the UV granules and the Ire1 foci–, all of them induced by specific cell damage factors, contribute to cell survival.
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影响因子：
7.8
作者：
Buchan, J. Ross;Muhlrad, Denise;Parker, Roy
通讯作者：
Parker, Roy
DOI：
10.1083/jcb.136.4.761
发表时间：
1997-02-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bashkirov VI;Scherthan H;Solinger JA;Buerstedde JM;Heyer WD
通讯作者：
Heyer WD
影响因子：
4.1
作者：
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通讯作者：
Mayr, Georg W.
影响因子：
4.5
作者：
Bedard, KM;Walter, BL;Semler, BL
通讯作者：
Semler, BL
影响因子：
64.8
作者：
Aragon, Tomas;van Anken, Eelco;Pincus, David;Serafimova, Iana M.;Korennykh, Alexei V.;Rubio, Claudia A.;Walter, Peter
通讯作者：
Walter, Peter