Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study.
Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study.
复制标题
高血糖对阿尔茨海默型痴呆患者记忆和激素水平的影响：一项纵向研究。
DOI：
10.1037//0735-7044.107.6.926
复制
发表时间：
1993
影响因子：
1.9
通讯作者：
Cryer,PE
中科院分区：
文献类型：
--
作者：
Craft,S;Dagogo-Jack,SE;Wiethop,BV;Murphy,C;Nevins,RT;Fleischman,S;Rice,V;Newcomer,JW;Cryer,PE
高血糖对激素水平、代谢物水平和记忆表现的影响在22名患有非常轻度和轻度可能的阿尔茨海默型痴呆（DAT）的受试者和12名正常老年人中进行了研究。在初始和18个月随访时，在3种血糖状况（空腹基线、175 mg/dl和225 mg/dl）下对受试者进行检测。最初，非常轻度DAT的成人在225 mg/dl葡萄糖条件下相对于基线表现出记忆促进和血浆胰岛素升高。在随访中，痴呆进展的非常轻度DAT患者显示胰岛素和高血糖记忆促进显著降低。基础胰岛素和皮质醇水平随时间的变化与DAT受试者的记忆变化相关。这些结果表明，葡萄糖调节异常可能有助于DAT的病理生理。
The effect of hyperglycemia on hormone levels, metabolite levels, and memory performance was examined in 22 subjects with very mild and mild probable dementia of the Alzheimer type (DAT) and in 12 normal elderly adults. Subjects were tested in 3 plasma glucose conditions (fasting baseline, 175 mg/dl, and 225 mg/dl) at initial and 18-month follow-up sessions. Initially, adults with very mild DAT showed memory facilitation and elevations in plasma insulin in the 225-mg/dl glucose condition relative to baseline. At follow-up, very mild DAT patients whose dementia had progressed showed significant decreases in insulin and hyperglycemic memory facilitation. Changes in basal insulin and cortisol levels over time were correlated with memory changes for DAT subjects. These results suggest that glucoregulatory abnormalities may contribute to the pathophysiology of DAT.